Cyclooxygenase-2 (COX-2), the enzyme at the rate-limiting step of prostanoid production,
has been found to be overexpressed in human lung cancer. To evaluate lung tumor COX-2 …

… Portanova et al. … Portanova et al. … Lynch, PC Isakson, and Jp Portanova. 1995.
Characterization of a monoclonal antibody that neutralizes the activi W ofprostaglandin E2…

PGs derived from cyclooxygenase-2 (COX-2), in particular PGE 2 , play important roles in
the initiation of inflammation and pain. In the present study, we evaluated the role of COX-2-…

During Ag-driven development of memory B cells, Ab V genes are modified by somatic
mutagenesis. Although V gene somatic mutations have important biologic consequences in both …

Studies have documented ethnic differences in advance directive (AD) completion, with
lower rates in minority groups. Of those with ADs, blacks are more likely than whites to prefer …

Background Public perceptions of cardiopulmonary resuscitation (CPR) can be influenced
by the media. Nearly two decades ago, a study found that the rates of survival following CPR …

The current study examines the role of the L3T4 T cell subset in the development of lupus-like
autoimmunity and lymphoproliferation in lpr-bearing mice. Chronic treatment of MRL-lpr/…

Beginning with sulphadiazine in 1945, various drugs have been implicated in the induction
of a syndrome with clinical and serologic features resembling systemic lupus erythematosus (…

SD0006 is a diarylpyrazole that was prepared as an inhibitor of p38 kinase-α (p38α). In vitro,
SD0006 was selective for p38α kinase over 50 other kinases screened (including p38γ and …

… and J. Portanova, unpublished data), administered ip twice weekly, was begun on day 10
or 18. Rats were sacrificed at day 21, 2 to 4 h after the last drug administration. The severity of …