Synthesis and characterization of NESS 0327: a novel putative antagonist of the CB1 cannabinoid receptor

S Ruiu, GA Pinna, G Marchese, JM Mussinu… - … of Pharmacology and …, 2003 - ASPET
… are reported in the following order: multiplicity (s, singlet; d, doublet; t, triplet; q, quartet; m,
multiplet; dd, double doublet; br s, broad singlet), number of protons, coupling constants (J) in …

Tricyclic pyrazoles. Part 1: synthesis and biological evaluation of novel 1, 4-dihydroindeno [1, 2-c] pyrazol-based ligands for CB1and CB2 cannabinoid receptors

JM Mussinu, S Ruiu, AC Mulè, A Pau… - Bioorganic & medicinal …, 2003 - Elsevier
Cannabinoids receptors, cellular elements of the endocannabinoid system, have been the
focus of extensive studies because of their potential functional role in several important …

Tricyclic pyrazoles. Part 2: Synthesis and biological evaluation of novel 4, 5-dihydro-1H-benzo [g] indazole-based ligands for cannabinoid receptors

G Murineddu, S Ruiu, JM Mussinu, G Loriga… - Bioorganic & medicinal …, 2005 - Elsevier
A series of 4,5-dihydro-1H-benzo[g]indazole-3-carboxamides (2a–k) as analogues of the
previously reported CB 2 ligands 6-chloro- and 6-methyl-1-(2′,4′-dichlorophenyl)-N-…

Chromophore-modified bis-benzo [g] indole carboxamides: synthesis and antiproliferative activity of bis-benzo [g] indazole-3-carboxamides and related dimers

GA Pinna, MA Pirisi, JM Mussinu, G Murineddu… - Il Farmaco, 2003 - Elsevier
Tricyclic pyrazole dimers that comprise two kinds of CONH(CH 2 ) n N(CH 3 )(CH 2 ) n
NHCO bridges to which are linked potential DNA-intercalating groups such as 1H-benzo[g]…

N-3 (9)-Arylpropenyl-N-9 (3)-propionyl-3, 9-diazabicyclo [3.3. 1] nonanes as μ-Opioid receptor agonists. Effects on μ-Affinity of arylalkenyl chain modifications

…, G Loriga, G Murineddu, JM Mussinu… - Bioorganic & medicinal …, 2002 - Elsevier
… -9-arylpropenyl isomers (2b–j) as analogues of the previously … Several compounds (1e,i,j–2d,e,f,g,j)
exhibited a μ-affinity in … .1]nonanes (1b–j) and related reverted analogues (2b–j), in …

Synthesis and D2-like binding affinity of new derivatives of N-(1-ethyl-2-pyrrolidinylmethyl)-4, 5-dihydro-1H-benzo [g] indole-3-carboxamide and related 4H-[1] …

GA Pinna, MA Pirisi, G Chelucci, JM Mussinu… - Bioorganic & medicinal …, 2002 - Elsevier
Various new derivatives and structural analogues of N-(1-ethyl-2-pyrrolidinylmethyl)-4,5-dihydro-1H-benzo[g]indole-3-carboxamide
(2a), a representative term of a series of 2-…

Synthesis and cytotoxicity of bis(benzo[g]indole‐3‐carboxamides) and related compounds

…, GE Grella, L Gherardini, JM Mussinu… - … der Pharmazie: An …, 2001 - Wiley Online Library
A series of bis(benzo[g]indoles) bridged by CX‐(CH 2 ) n N(Me)(CH 2 ) n ‐CX (X = O, S, H 2
; n = 2,3) was synthesized as bifunctional antitumor agents and evaluated for cytotoxic …

Synthesis and cytotoxicity evaluation of thiophene analogues of 1-methyl-2, 3-bis (hydroxymethyl) benzo [g] indole bis [N-(2-propyl) carbamate]

MA Pirisi, G Murineddu, JM Mussinu, GA Pinna - Il Farmaco, 2002 - Elsevier
The cytotoxicity of the bis[N-(2-propyl)carbamates] 2 and 3 which are linked to thieno[i,jg]indole
scaffolds through methylene bridges were studied as thiophene analogues of prototype 1…

[CITATION][C] Tricyclic pyrazoles

G Murineddu, S Ruiu, JM Mussinu - Part

[CITATION][C] , A. Pau, MAM Carai, G. Loriga, G. Murineddu and GA Pinna

JM Mussinu, S Ruiu, AC Mule - Bioorg. Med. Chem, 2008