Corpus cavernosum from men with vasculogenic impotence is partially resistant to adenosine relaxation due to endothelial A2B receptor dysfunction

…, JM Lafuente-de-Carvalho… - … of Pharmacology and …, 2006 - ASPET
Although adenosine has been implicated in penile erection in human males, the receptor
subtype responsible for adenosine regulation of human corpus cavernosum (HCC) smooth …

Decreased ecto-NTPDase1/CD39 activity leads to desensitization of P2 purinoceptors regulating tonus of corpora cavernosa in impotent men with endothelial …

…, JM Lafuente-de-Carvalho… - … , and Nucleic Acids, 2008 - Taylor & Francis
Vascular responses to adenine nucleotides in human corpora cavernosa from men with
vasculogenic erectile dysfunction were investigated. We also evaluated the catabolism of …

Testicular cancer awareness and knowledge: Is it the same? Exploratory study in a mixed-gender population

IC Braga, J Cabral, N Louro… - Journal of Cancer …, 2017 - Springer
Testicular cancer (TC) is among the most common malignancies in the young male.
Awareness plays an important role, because delay in diagnosis affects outcome. Testicular self-…

Hyperactivity of cholinergic nerves associated with decreased hydrolysis of ATP in obstructed human bladders

…, JM Lafuente-de-Carvalho… - Autonomic …, 2007 - autonomicneuroscience.com
Contractions of the human bladder during voiding are exclusively mediated by acetylcholine
(ACh) via muscarinic M3 receptors. Atropine-resistant contractions have been reported …

786: Decreased ECTO-NTPDASE 1 Activity Reduces Adenosine Formation from the Hydrolysis of Adenine Nucleotides in the Corpus Cavernosum from Impotent Men

…, JM Lafuente-de-Carvalho… - The Journal of …, 2007 - auajournals.org
RESULTS: HCC possesses a high ecto-NTPDase 1 activity converting ATP (or ADP)
directly into AMP, which is then dephosphorylated into adenosine by ecto-5'-nucleotidase. …

S5. 7 Sustained P2X3 facilitation of acetylcholine release contributes to bladder hyperactivity in humans with benign prostatic hyperplasia

…, JM LaFuente-de-Carvalho… - Autonomic …, 2009 - autonomicneuroscience.com
The underlying mechanism by which benign prostatic hyperplasia causes lower urinary tract
instability is not fully understood. Contractions of normal human bladder are exclusively …

249: Decreased Hydrolysis of ATP Acting Via P2X Receptors Favour Cholinergic Nerve Hyperactivity in Human Obstructed Bladders

…, JM Lafuente-de-Carvalho… - The Journal of …, 2007 - auajournals.org
… R1240 (n = 5) also significantly increased IUP (3-1000 j.Jg/kg) and MAP (100 -1000 j.Jg/kg)
with a maximum change of 50.7 ± 3.0 mmHg and 33.1 ± 3.5 mmHg, respectively. R1484 (n=4…

[CITATION][C] 276 ACTIVATION OF P2× 1 PURINOCEPTORS FACILITATE EVOKED ACETYLCHOLINE RELEASE IN HUMAN OBSTRUCTED BLADDERS

…, I Silva, JM Lafuente-De-Carvalho… - European Urology …, 2009 - infona.pl
… Silva, JM Lafuente-De-Carvalho, P. Correia-De-SÁ …

[CITATION][C] Loss of balance between excitatory P2X3 and inhibitory A1 receptors contribute to cholinergic hyperactivity in obstructed human bladder

…, T Magalhães-Cardoso, J Lafuente-de-Carvalho… - Basic Clin Pharmacol …, 2010

[CITATION][C] Dual regulation of human penile smooth muscle tone by P2 purinoceptors: possible implications in erectile dysfunction

…, JM Lafuente-de-Carvalho… - PURINERGIC …, 2008 - … VAN GODEWIJCKSTRAAT 30 …