User profiles for J. Jakubik

jocelyn jakubik

- Verified email at mesoscale.com - Cited by 597

Johannes Jakubik

- Verified email at ethz.ch - Cited by 225

Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors

J Jakubík, L Bačáková, EE El-Fakahany, S Tuček - Molecular pharmacology, 1997 - ASPET
It is well known that allosteric modulators of muscarinic acetylcholine receptors can both
diminish and increase the affinity of receptors for their antagonists. We investigated whether the …

[HTML][HTML] Curcumin from turmeric rhizome: A potential modulator of DNA methylation machinery in breast cancer inhibition

…, A Kaufman-Szymczyk, A Szymanska-Kolba, J Jakubik… - Nutrients, 2021 - mdpi.com
One of the most systematically studied bioactive nutraceuticals for its benefits in the management
of various diseases is the turmeric-derived compounds: curcumin. Turmeric obtained …

Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors

…, S Bot, C Caillet, T Convard, J Jakubik… - Journal of medicinal …, 2011 - ACS Publications
A novel series of 3-aryl-phospho-indole (API) non-nucleoside reverse transcriptase inhibitors
of HIV-1 was developed. Chemical variation in the phosphorus linker led to the discovery …

[HTML][HTML] An introduction to the Marburg virus vaccine consortium, MARVAC

…, R Hunegnaw, J Jakubik, J Ledgerwood… - PLoS …, 2022 - journals.plos.org
The emergence of Marburg virus (MARV) in Guinea and Ghana triggered the assembly of the
MARV vaccine “MARVAC” consortium representing leaders in the field of vaccine research …

Analysis of forging defects for selected industrial die forging processes

M Hawryluk, J Jakubik - Engineering Failure Analysis, 2016 - Elsevier
The main goal of this paper is to identify defects in forgings in selected die forging processes.
The major problem is the formation of underfills due to air pockets between the forging and …

[HTML][HTML] Data-centric artificial intelligence

J Jakubik, M Vössing, N Kühl, J Walk… - Business & Information …, 2024 - Springer
Data-centric artificial intelligence (data-centric AI) represents an emerging paradigm that
emphasizes the importance of enhancing data systematically and at scale to build effective and …

Comparison of six methods for the detection of causality in a bivariate time series

A Krakovská, J Jakubík, M Chvosteková, D Coufal… - Physical Review E, 2018 - APS
In this comparative study, six causality detection methods were compared, namely, the Granger
vector autoregressive test, the extended Granger test, the kernel version of the Granger …

[HTML][HTML] Age-related changes in human sperm DNA integrity

A Rosiak-Gill, K Gill, J Jakubik, M Fraczek… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Abnormal standard semen characteristics and reduced sperm chromatin maturity can appear
with increasing male age. However, the influence of paternal age on semen parameters is …

Causality, dynamical systems and the arrow of time

M Paluš, A Krakovská, J Jakubík… - … Journal of Nonlinear …, 2018 - pubs.aip.org
Any scientific discipline strives to explain causes of observed phenomena. Studying
phenomena evolving in time and providing measurable quantities which can be registered in …

Dietary antioxidant intake decreases carotid intima media thickness in women but not in men: A cross-sectional assessment in the Kardiovize study

A Maugeri, J Hruskova, J Jakubik, S Kunzova… - Free Radical Biology …, 2019 - Elsevier
Objective Atherosclerosis is a major contributor to cardiovascular disease, with a higher
burden on men than women during the occupational age. Intake of individual dietary …