User profiles for J. Fichna

Jakub Fichna

Medical University of Lodz, Poland
Verified email at umed.lodz.pl
Cited by 10407

[HTML][HTML] The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

…, A Zielińska, E Poleszak, J Fichna… - Pharmacological …, 2021 - Elsevier
Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional
communication between the gut and the brain suggesting that the gut microbes may shape …

The endomorphin system and its evolving neurophysiological role

J Fichna, A Janecka, J Costentin, JC Do Rego - Pharmacological reviews, 2007 - ASPET
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH 2 ) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH 2 ) are
two endogenous opioid peptides with high affinity and remarkable selectivity for the μ-opioid …

[HTML][HTML] The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

A Piechota-Polanczyk, J Fichna - Naunyn-Schmiedeberg's archives of …, 2014 - Springer
In this review, we focus on the role of oxidative stress in the aetiology of inflammatory bowel
diseases (IBD) and colitis-associated colorectal cancer and discuss free radicals and free …

Opioid receptors and their ligands

A Janecka, J Fichna, T Janecki - Current topics in medicinal …, 2004 - ingentaconnect.com
This review gives a historical perspective, summarizing approximately 25 years of research
on opioids. The “typical” opioid peptides produced in the brain, “atypical” opioids encrypted …

[HTML][HTML] Distribution, function and physiological role of melatonin in the lower gut

CQ Chen, J Fichna, M Bashashati, YY Li… - World journal of …, 2011 - ncbi.nlm.nih.gov
Melatonin is a hormone with endocrine, paracrine and autocrine actions. It is involved in the
regulation of multiple functions, including the control of the gastrointestinal (GI) system …

[HTML][HTML] Physiology, signaling, and pharmacology of opioid receptors and their ligands in the gastrointestinal tract: current concepts and future perspectives

M Sobczak, M Sałaga, MA Storr, J Fichna - Journal of gastroenterology, 2014 - Springer
Opioid receptors are widely distributed in the human body and are crucially involved in
numerous physiological processes. These include pain signaling in the central and the …

Beneficial effects of probiotics, prebiotics, synbiotics, and psychobiotics in inflammatory bowel disease

…, M Zielińska, M Storr, J Fichna - Inflammatory bowel …, 2015 - academic.oup.com
Inflammatory bowel disease (IBD) is a group of diseases characterized by inflammation of
the small and large intestine and primarily includes ulcerative colitis and Crohn's disease. …

[HTML][HTML] Brain-gut interactions in IBS

J Fichna, M Storr - Frontiers in pharmacology, 2012 - frontiersin.org
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder with an estimated
prevalence of 10–20%. Current understanding of the pathophysiology of IBS is incomplete due to …

[HTML][HTML] The role of morphine in regulation of cancer cell growth

K Gach, A Wyrębska, J Fichna, A Janecka - … -Schmiedeberg's archives of …, 2011 - Springer
Morphine is considered the “gold standard” for relieving pain and is currently one of the
most effective drugs available clinically for the management of severe pain associated with …

Natural and synthetic α-methylenelactones and α-methylenelactams with anticancer potential

A Janecka, A Wyrębska, K Gach, J Fichna… - Drug Discovery …, 2012 - Elsevier
α-Methylene-γ- and δ-lactones, as well as α-methylene-γ- and δ-lactams, are plant-derived
compounds often used in traditional medicine for the treatment of inflammatory diseases. In …