We have examined the trafficking and metabolism of the β-amyloid precursor protein (APP),
an APP homolog (APLP1), and TrkB in neurons that lack PS1. We report that PS1-deficient …

Overexpression of the familial Alzheimer's disease gene Presenilin 2 (PS2) in nerve growth
factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or β…

The p3 peptide [amyloid β‐peptide (Aβ) 17–40/42], derived by α‐ and γ‐secretase cleavage
of the amyloid precursor protein (APP), is a major constituent of diffuse plaques in Alzheimer’…

Amyloid β-peptide (Aβ) is implicated as the toxic agent in Alzheimer's disease and is the
major component of brain amyloid plaques. In vitro, Aβ causes cell death, but the molecular …

The search for a clinically effective therapy for patients with Alzheimer's disease (AD) has
been long and arduous. In some circles the recent US Food and Drug Administration (FDA) …

Intrahippocamal injections of kainic acid (KA) significantly increase the expression of monocyte
chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) in …

The accumulation of amyloid β peptide (Aβ) is believed to be an early and critical event
leading to synapse and neuronal cell loss in Alzheimer's Disease (AD). Aβ itself is toxic to …

… Kusiak; Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity . J Cell
Biol 25 April 2005; 169 (2): 331–339. doi: https://doi.org/10.1083/jcb.200410041 …

The processing of Alzheimer's amyloid precursor protein was studied by Western blotting
during H 2 O 2 induced apoptosis in cultures of human neuroblastoma cells. A new 5.5 kDa …

In the present study we demonstrate low level expression of the laminin α2 chain in brain and
localize the α 2 protein to the capillary basement membrane. While in peripheral basement …