Caveolae and lipid rafts: G protein‐coupled receptor signaling microdomains in cardiac myocytes
A growing body of data indicates that multiple signal transduction events in the heart occur
via plasma membrane receptors located in signaling microdomains. Lipid rafts, enriched in …
via plasma membrane receptors located in signaling microdomains. Lipid rafts, enriched in …
Impact of anesthesia on cardiac function during echocardiography in mice
DM Roth, JS Swaney, ND Dalton… - American Journal of …, 2002 - journals.physiology.org
Anesthetics provide sedation and immobility facilitating echocardiography in mice, but influence
cardiac function. We studied the effects of intraperitoneal and inhaled anesthetic agents …
cardiac function. We studied the effects of intraperitoneal and inhaled anesthetic agents …
[HTML][HTML] Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components
Microtubules and actin filaments regulate plasma membrane topography, but their role in
compartmentation of caveolae-resident signaling components, in particular G protein-coupled …
compartmentation of caveolae-resident signaling components, in particular G protein-coupled …
A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model
JS Swaney, C Chapman, LD Correa… - British journal of …, 2010 - Wiley Online Library
Background and purpose: The aim of this study was to assess the potential of an antagonist
selective for the lysophosphatidic acid receptor, LPA 1 , in treating lung fibrosis We …
selective for the lysophosphatidic acid receptor, LPA 1 , in treating lung fibrosis We …
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase
JS Swaney, DM Roth, ER Olson… - Proceedings of the …, 2005 - National Acad Sciences
Transformation of fibroblasts to myofibroblasts, characterized by expression of α-smooth
muscle actin (α-SMA) and production of extracellular matrix (ECM) components, is a key event …
muscle actin (α-SMA) and production of extracellular matrix (ECM) components, is a key event …
Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma
…, G Bain, SF Brooks, CD King, JS Swaney… - Arthritis & …, 2011 - Wiley Online Library
Objective Scleroderma (systemic sclerosis [SSc]), is characterized by progressive multiorgan
fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of …
fibrosis. We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of …
Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-β-stimulated collagen production by cardiac fibroblasts
N Gellings Lowe, JS Swaney, KM Moreno… - Cardiovascular …, 2009 - academic.oup.com
Aims Following injury, fibroblasts transform into myofibroblasts and produce extracellular
matrix (ECM). Excess production of ECM associated with cardiac fibrosis severely inhibits …
matrix (ECM). Excess production of ECM associated with cardiac fibrosis severely inhibits …
Compartmentation of G-protein-coupled receptors and their signalling components in lipid rafts and caveolae
G-protein-coupled receptors (GPCRs) and post-GPCR signalling components are
expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity …
expressed at low overall abundance in plasma membranes, yet they evoke rapid, high-fidelity …
Pharmacokinetic and pharmacodynamic characterization of an oral lysophosphatidic acid type 1 receptor-selective antagonist
JS Swaney, C Chapman, LD Correa, KJ Stebbins… - … of Pharmacology and …, 2011 - ASPET
Lysophosphatidic acid (LPA) is a bioactive phospholipid that signals through a family of at
least six G protein-coupled receptors designated LPA 1–6 . LPA type 1 receptor (LPA 1 ) …
least six G protein-coupled receptors designated LPA 1–6 . LPA type 1 receptor (LPA 1 ) …
Increased smooth muscle cell expression of caveolin‐1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension
…, BP Head, U Yokoyama, JS Swaney… - The FASEB …, 2007 - Wiley Online Library
Vasoconstriction and vascular medial hypertrophy, resulting from increased intracellular [Ca
2+ ] in pulmonary artery smooth muscle cells (PASMC), contribute to elevated vascular …
2+ ] in pulmonary artery smooth muscle cells (PASMC), contribute to elevated vascular …