Blockade of the renin-angiotensin system was studied in male Sprague-Dawley rats during
long-term inhibition of nitric oxide synthase. Nitro-L-arginine-methyl ester (L-NAME) was …

Apomorphine, a nonselective dopamine receptor agonist, facilitates penile erection and is
effective in patients suffering from erectile dysfunction. The specific dopamine receptor subtype…

We developed S1QEL1.719, a novel bioavailable S1QEL (suppressor of site I Q electron
leak). S1QEL1.719 prevented superoxide/hydrogen peroxide production at site I Q of …

Levosimendan enhances cardiac contractility via Ca 2+ sensitization and induces vasodilation
through the activation of ATP-dependent K + and large-conductance Ca 2+ -dependent K …

The synthesis and characterization of a series of selective, orally bioavailable 1-(chroman-4-yl)urea
TRPV1 antagonists is described. Whereas first-generation antagonists that inhibit all …

Bimoclomol has been shown to increase an inducible member of the heat shock protein 70
family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral pretreatment of rats …

A series of 1,2,3,6-tetrahydropyridyl-4-carboxamides, exemplified by 6, have been synthesized
and evaluated for in vitro TRPV1 antagonist activity, and in vivo analgesic activity in …

Blockade of the histamine H 3 receptor (H 3 R) enhances central neurotransmitter release,
making it an attractive target for the treatment of cognitive disorders. Here, we present in vitro …

Evaluation of multiple structurally distinct series of melanin concentrating hormone receptor
1 antagonists in an anesthetized rat cardiovascualar assay led to the identification of a …

Endothelial dysfunction increases cardiovascular disease risk in chronic kidney disease (CKD).
This study investigates whether VDR activation affects endothelial function in CKD. The 5…