SSR240612 [(2R)-2-[((3R)-3-(1, 3-benzodioxol-5-yl)-3-{[(6-methoxy-2-naphthyl) sulfonyl] amino} propanoyl) amino]-3-(4-{[2R, 6S)-2, 6-dimethylpiperidinyl] methyl} …
…, F Guagnini, K Urban-Szabo, JP Martinolle… - … of Pharmacology and …, 2004 - ASPET
The biochemical and pharmacological properties of a novel non-peptide antagonist of the
bradykinin (BK) B 1 receptor, SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-{[(6-…
bradykinin (BK) B 1 receptor, SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-{[(6-…
SSR126768A (4-chloro-3-[(3R)-(+)-5-chloro-1-(2, 4-dimethoxybenzyl)-3-methyl-2-oxo-2, 3-dihydro-1H-indol-3-yl]-N-ethyl-N-(3-pyridylmethyl)-benzamide …
…, C Advenier, E Naline, M Bardou, JP Martinolle… - … of Pharmacology and …, 2004 - ASPET
… Rinsed labeled sections were placed on a phosphor-imaging plate (Fuji, Tokyo, Japan)
for 2 days and further analyzed with a Bio-Image analyser (BAS 2000; Fuji) as described …
for 2 days and further analyzed with a Bio-Image analyser (BAS 2000; Fuji) as described …
Altered contractility of circular and longitudinal muscle in TNBS-inflamed guinea pig ileum
JP Martinolle, R Garcia-Villar… - American Journal of …, 1997 - journals.physiology.org
Intestinal motility disorders are often associated with gut inflammation. We evaluated, in
vitro under isometric conditions, changes in contractility of longitudinal and circular muscle …
vitro under isometric conditions, changes in contractility of longitudinal and circular muscle …
Considerations on nonclinical approaches to modeling risk factors of suicidal ideation and behavior
…, KE Cannon, M Liu, MJ Kallman, JP Martinolle… - Regulatory toxicology …, 2017 - Elsevier
Given the serious nature of suicidal ideation and behavior (SIB) and the possibility of
treatment-emergent SIB, pharmaceutical companies are now applying more proactive approaches …
treatment-emergent SIB, pharmaceutical companies are now applying more proactive approaches …
Inverse regulation of α-and β-adrenoceptors during trinitrobenzenesulfonic acid (TNB)-induced inflammation in guinea-pig small intestine
JP Martinolle, J More, N Dubech, R Garcia-Villar - Life sciences, 1993 - Elsevier
The hypothesis has been raised that intestinal motor disturbances induced by inflammation
of the digestive tract may reflect alterations in intestinal cell-membrane receptors. This …
of the digestive tract may reflect alterations in intestinal cell-membrane receptors. This …
Intraluminal excretion of PAF, lysoPAF, and acetylhydrolase in patients with ulcerative colitis
R Guimbaud, A Izzo, JP Martinolle, N Vidon… - Digestive diseases and …, 1995 - Springer
PAF-acether (PAF) is a phospholipid synthesized by numerous inflammatory cells. PAF can
produce several pathological changes in various organs, especially in the colon. In animals …
produce several pathological changes in various organs, especially in the colon. In animals …
Functional evidence for NO‐synthase activation by substance P through a mechanism not involving classical tachykinin receptors in guinea‐pig ileum in vitro
R Garcia‐Villar, C Dupuis, JP Martinolle… - British journal of …, 1996 - Wiley Online Library
1 This study tested the hypothesis that a nitric oxide synthase (NOS) was activated in guinea‐pig
ileum in vitro in response to substance P (SP), and attempted to characterize the …
ileum in vitro in response to substance P (SP), and attempted to characterize the …
[PDF][PDF] SSR126768A: A new selective and orally active oxytocin receptor antagonist for the prevention of preterm labor
…, C Advenier, E Naline, M Bardou, JP Martinolle… - J Pharmacol Exp …, 2004 - Citeseer
SSR126768A, a new potent and selective, orally-active oxytocin (OT) receptor antagonist
was characterized in several biochemical and pharmacological models. In binding studies, …
was characterized in several biochemical and pharmacological models. In binding studies, …
The contractility of circular and longitudinal intestinal smooth muscle is differentially altered during trinitrobenzenesulfonic acid induced ileitis in guinea pigs
JP Martinolle, RG Villar, J Fioramonti… - XV Int Symp on …, 1995 - hal.science
… Jean-Pierre Martinolle, Rafael Garcia Villar, Jean Fioramonti, Lionel Bueno … Jean-Pierre
Martinolle, Rafael Garcia Villar, Jean Fioramonti, Lionel Bueno. The contractility of circular …
Martinolle, Rafael Garcia Villar, Jean Fioramonti, Lionel Bueno. The contractility of circular …
[PDF][PDF] Optimization of hERG screening using IonFlux HT automated system
…, P Verges, P Brun, JP MARTINOLLE - Journal of …, 2012 - ionflux.fluxionbio.com
The human Ether-à-go-go related gene (hERG) represents the molecular correlate of the IKr
current, one of the several potassium currents involved in cardiac action potential …
current, one of the several potassium currents involved in cardiac action potential …