Objective: Migraine is associated with cardiovascular disorders but the underlying
mechanisms are unknown. Arterial structure and function are important determinants of …

Background To document covariates which contribute to inter-individual variability in propofol
pharmacokinetics in preterm and term neonates. Methods Population pharmacokinetics …

Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the only …

Interictal serum C-reactive protein (CRP) was measured in 50 young adult patients with
migraine and compared with 50 controls. The median CRP level was 1.42 mg/l in patients with …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Calcitonin gene‐related peptide (CGRP)
was first described as a potent vasodilator. • CGRP is also increasingly recognized as a …

What is already known about this subject • Capsaicin rapidly produces local neurogenic
inflammation (characterized by oedema and erythema) when locally administered to the human …

Objective We aimed to evaluate the role of endothelial-dependent and endothelial-independent
vascular reactivity in retinal vasculopathy with cerebral leukoencephalopathy and …

Background and Objectives We aimed to study the impact of size, maturation and cytochrome
P450 2D6 (CYP2D6) genotype activity score as predictors of intravenous tramadol …

As migraine is associated with an increased risk for ischaemic stroke and peripheral
vasospastic disorders, it was hypothesized that interictal vascular changes may be present in …

MRK-409 binds to α1-, α2-, α3- and α5-containing human recombinant GABA A receptors
with comparable high affinity (0.21–0.40 nM). However, MRK-409 has greater agonist efficacy …