Role of HMGB1 signaling in the inflammatory process in diabetic retinopathy

JJ Steinle - Cellular signalling, 2020 - Elsevier
High mobility group box 1 (HMGB1) is a key player in retinal inflammation. HMGB1 is a
danger associated protein pattern receptor which can sense high glucose as a stressor. …

[HTML][HTML] Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

…, Q Zhang, RC Brennan, D Johnson, JJ Steinle… - BMC cancer, 2017 - Springer
Background Retinoblastoma (Rb) is the most common primary intraocular tumor in children.
Local treatment of the intraocular disease is usually effective if diagnosed early; however …

[HTML][HTML] Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway

JJ Steinle, CJ Meininger, R Forough, G Wu… - Journal of Biological …, 2002 - ASBMB
The goals of this study were 2-fold: 1) to determine whether stimulation of Eph B4 receptors
promotes microvascular endothelial cell migration and/or proliferation, and 2) to elucidate …

[HTML][HTML] miR-146a Attenuates Inflammatory Pathways Mediated by TLR4/NF-κB and TNFα to Protect Primary Human Retinal Microvascular Endothelial Cells Grown …

EA Ye, JJ Steinle - Mediators of inflammation, 2016 - hindawi.com
… Jiang, JJ Toutounchian, C. Soderland, C. Ryan Yates, and JJ Steinle, “Insulin-like growth …
Miller, and JJ Steinle, “Reduced insulin receptor signaling in retinal Müller cells cultured in …

[HTML][HTML] β3-adrenergic receptors regulate retinal endothelial cell migration and proliferation

JJ Steinle, GW Booz, CJ Meininger, JNE Day… - Journal of Biological …, 2003 - ASBMB
Sympathetic nerves may play a role in vascular disorders of the eye. In the present study, we
hypothesized that activation of β 3 -adrenergic receptors on retinal endothelial cells would …

Regional regulation of choroidal blood flow by autonomic innervation in the rat

JJ Steinle, D Krizsan-Agbas… - American Journal of …, 2000 - journals.physiology.org
Regional influences of parasympathetic and sympathetic innervation on choroidal blood
flow were investigated in anesthetized rats. Parasympathetic pterygopalatine neurons were …

[HTML][HTML] miR-15b/16 protects primary human retinal microvascular endothelial cells against hyperglycemia-induced increases in tumor necrosis factor alpha and …

EA Ye, JJ Steinle - Journal of neuroinflammation, 2015 - Springer
Background Mechanisms underlying the pathology of diabetic retinopathy are still not
completely understood. Increased understanding of potential cellular pathways responsive to …

[HTML][HTML] miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high …

EA Ye, JJ Steinle - Vision research, 2017 - Elsevier
microRNA (miRNA) play critical roles in the pathological processes of diabetic retinopathy,
including inflammatory responses, insulin signaling, and angiogenesis. In addition to their …

[HTML][HTML] miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling

…, J Jan, S Gaddipati, S Suvas, JJ Steinle - Journal of …, 2016 - Springer
Background Hyperglycemia is a significant risk factor for diabetic retinopathy and induces
increased inflammatory responses and retinal leukostasis, as well as vascular damage. …

[HTML][HTML] Role of β-adrenergic receptors in inflammatory marker expression in Muller cells

RJ Walker, JJ Steinle - Investigative ophthalmology & visual …, 2007 - arvojournals.org
purpose. To determine whether β-adrenergic receptors are involved in the modulation of
inflammatory cytokines in Müller cells in a hyperglycemic environment. methods. Rat Müller …