Therapeutics that are designed to engage RNA interference (RNAi) pathways have the
potential to provide new, major ways of imparting therapy to patients 1 , 2 . Long, double-…

Nanoparticles are being investigated for numerous medical applications and are showing
potential as an emerging class of carriers for drug delivery. Investigations on how the …

The histological analysis of tissue samples, widely used for disease diagnosis, involves
lengthy and laborious tissue preparation. Here, we show that a convolutional neural network …

Small interfering RNA (siRNA)-based therapies are emerging as a promising new anticancer
approach, and a small number of Phase I clinical trials involving patients with solid tumours …

Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based
siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the …

Nanoparticle-based experimental therapeutics are currently being investigated in numerous
human clinical trials. CALAA-01 is a targeted, polymer-based nanoparticle containing small …

Biophysical and pharmacokinetic properties of five analogs of ISIS 3082, a 20-mer
phosphorothioate oligodeoxynucleotide that inhibits the expression of mouse intercellular adhesion …

Pathology is practiced by visual inspection of histochemically stained tissue slides. While
the hematoxylin and eosin (H&E) stain is most commonly used, special stains can provide …

Rationale & Objective Kidney biopsy data inform us about pathologic processes associated
with infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We …

We describe the trajectory of the human sex ratio from conception to birth by analyzing data
from (i) 3- to 6-d-old embryos, (ii) induced abortions, (iii) chorionic villus sampling, (iv) …