Mixed-variable symplectic integrators exhibit no long-term accumulation of energy error,
beyond that owing to round-off, and they are substantially faster than conventional N-body …

… The integrations used a new hybrid symplectic integrator algorithm (Chambers 1999) and
the Mercury integrator package (Chambers and Migliorini 1997). The integration algorithm is a …

There have been major improvements in instrumentation, field survey design and data inversion
techniques for the geoelectrical method over the past 25 years. Multi-electrode and multi…

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress,
resulting in activation of the unfolded protein response (UPR) that aims to restore protein …

We simulate the late stages of terrestrial-planet formation using N-body integrations, in three
dimensions, of disks of up to 56 initially isolated, nearly coplanar planetary embryos, plus …

A system of two small planets orbiting the Sun on low-eccentricity, low-inclination orbits is
stable with respect to close encounters if the initial semi-major axis difference, Δ, measured in …

Unlike gas-giant planets, we lack examples of terrestrial planets orbiting other Sun-like stars
to help us understand how they formed. We can draw hints from elsewhere though. …

… , and the inhibition was even more prolonged when the OP compound required bioactivation
which extended the time of entry of the active metabolite into the circulation (Chambers and …

The combination of relative nutrient deprivation and dysregulation of protein synthesis make
malignant cells especially prone to protein misfolding. Endoplasmic reticulum stress, which …

The blood system is sustained by a pool of haematopoietic stem cells (HSCs) that are long-lived
due to their capacity for self-renewal. A consequence of longevity is exposure to stress …