Detailed knowledge about the patterns of molecular alterations during epileptogenesis is a
presupposition for identifying targets for preventive or disease-modifying approaches, as well …

Considering its role as a major blood–brain barrier gatekeeper, the dynamic regulation of
the efflux transporter P-glycoprotein is of considerable functional relevance. In particular, …

Objective Anticonvulsive monotherapy fails to be effective in one third of patients with epilepsy
resulting in the need for polytherapy regimens. However, with the still limited knowledge, …

Excessive activation of inflammatory signaling pathways seems to be a hallmark of
epileptogenesis. Positron emission tomography (PET) allows in vivo detection of brain inflammation …

Breast cancer resistance protein (BCRP) functions as a major molecular gatekeeper at the
blood–brain barrier. Considering its impact on access to the brain by therapeutic drugs and …

As a member of the multidrug-resistance associated protein (MRP) family, MRP2 affects the
brain entry of different endogenous and exogenous compounds. Considering the role of this …

The tetracycline antibiotic minocycline can exert strong anti-inflammatory, antioxidant, and
antiapoptotic effects. There is cumulating evidence that epileptogenic brain insults trigger …

The glycine co-agonist binding site of the N-methyl-d-aspartat (NMDA) receptor is discussed
as an interesting target for different central nervous system diseases. Antagonism at this co-…

The neuroprotective and anti-inflammatory effects of the peroxisome proliferator-activated
receptor γ (PPARγ) agonist rosiglitazone are of particular interest for disease-modifying and …

The neural cell adhesion molecule peptide mimetic fibroblast growth loop (FGL) proved to
exert neuroprotective, neurotrophic, and anti-inflammatory effects in different in vitro and in …