Chromogranins as regulators of exocytosis

…, N Domínguez, MR Arnau, JD Machado - Journal of …, 2010 - Wiley Online Library
… Other drugs like estrogens also slow down exocytosis through a non-genomic mechanism
that involves cAMP (Machado et al. 2002a). The activation of these two pathways produces a …

[HTML][HTML] Zika virus pathogenesis: a battle for immune evasion

…, D Márquez-Arce, R Trujillo-González, JD Machado… - Vaccines, 2021 - mdpi.com
Zika virus (ZIKV) infection and its associated congenital and other neurological disorders,
particularly microcephaly and other fetal developmental abnormalities, constitute a World …

The crucial role of chromogranins in storage and exocytosis revealed using chromaffin cells from chromogranin A null mouse

MS Montesinos, JD Machado, M Camacho… - Journal of …, 2008 - Soc Neuroscience
… MC, MSM, YGM, and JD are recipients of scholarships from the MEC. DAdlR is the recipient
of a “Ramón y Cajal” contract. OHV is the recipient of a fellowship from the MEC and the …

[HTML][HTML] The dynamic nature of exocytosis from large secretory vesicles. A view from electrochemistry and imaging

R Borges, C Gu, JD Machado, AG Ewing - Cell Calcium, 2023 - Elsevier
In this brief review, we discuss the factors that modulate the quantum size and the kinetics of
exocytosis. We also discuss the determinants which motivate the type of exocytosis from the …

ATP: The crucial component of secretory vesicles

…, R Borges, JD Machado - Proceedings of the …, 2016 - National Acad Sciences
The colligative properties of ATP and catecholamines demonstrated in vitro are thought to
be responsible for the extraordinary accumulation of solutes inside chromaffin cell secretory …

Automatic analysis for amperometrical recordings of exocytosis

F Segura, MA Brioso, JF Gomez, JD Machado… - Journal of neuroscience …, 2000 - Elsevier
Amperometry is a widely used technique for monitoring the secretion of catecholamines (CA)
by exocytosis. The use of carbon fibre microelectrodes allows the on-line recording of CA …

[HTML][HTML] HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis

B Tejera-Segura, M Macía-Díaz, JD Machado… - Arthritis Research & …, 2017 - Springer
Background Lipid profiles appear to be altered in rheumatoid arthritis (RA) patients because
of disease activity and inflammation. Cholesterol efflux capacity (CEC), which is the ability of …

cAMP modulates exocytotic kinetics and increases quantal size in chromaffin cells

JD Machado, A Morales, JF Gomez, R Borges - Molecular Pharmacology, 2001 - ASPET
The role of cAMP/cAMP-dependent protein kinase (PKA) on the late phase of exocytosis
has been studied by amperometry on Ba 2+ -stimulated single bovine chromaffin cells. …

Intragranular pH rapidly modulates exocytosis in adrenal chromaffin cells

M Camacho, JD Machado… - Journal of …, 2006 - Wiley Online Library
Several drugs produce rapid changes in the kinetics of exocytosis of catecholamines, as
measured at the single event level with amperometry. This study is intended to unveil whether …

Impaired HDL cholesterol efflux capacity in systemic lupus erythematosus patients is related to subclinical carotid atherosclerosis

…, E Armas-González, JD Machado… - …, 2020 - academic.oup.com
Objectives Lipid profiles appear to be altered in SLE patients due to disease activity and
inflammation. Cholesterol efflux capacity (CEC) is the ability of high-density lipoprotein …