The serotonin 2C (5‐HT 2C ) receptor couples to both phospholipase C (PLC)‐inositol
phosphate (IP) and phospholipase A 2 (PLA 2 )‐arachidonic acid (AA) signalling cascades. …

In cell systems where ligand-independent receptor activity is optimized (such as when
receptors are overexpressed or mutated), acute treatment with inverse agonists reduces basal …

DNA lesions induced by alkylating agents are repaired by two canonical mechanisms, base
excision repair dependent on poly(ADP) ribose polymerase 1 (PARP1) and the other …

The 5-hydroxytryptamine (5-HT) 1A receptor system plays a prominent role in a variety of
physiological functions and behaviors and regulation of the responsiveness of this receptor …

Coactivation of purinergic (P 2Y ) receptors reduces agonist efficacy at serotonin 1B (5-HT
1B ), but not 5-HT 1A receptors. Herein, we report that pretreatment for 5 min with the P 2Y …

… , by JD Hem_ __________________________________ 57 (D) Complexes of ferrous iron
with tannic acid, by JD … , and cupric ions, by JD Hem and MW Skougstad________________ …

Temozolomide is the first-choice DNA alkylating agent and has been commonly used in
oncology over the last several decades. The cytotoxicity that temozolomide elicits through the …

Amounts of iron in solution in natural water at equilibrium are related to the pH and Eh of the
solution. Important ionic species present include Fe+++, FeOH++, Fe (OH)+ 2, Fe++, and …

… , and Eh have been discussed by Hem and Cropper (1959), who proposed a technique for
… Hem, JD, 1960, Restraints on dissolved ferrous iron imposed by bicarbonate, redox potential…

… Watts (personal communication) from observations on the Anglo-Australian telescope, Our
ephemeris predicts a minimum at JD, 2445 128.140 and a maximum at JD, 2445132.278 …