The transport properties and growth-inhibitory potential of 37 classic and novel antifolate
compounds have been tested in vitm against human and murine ceillines expressing …

GPI-linked membrane folate receptors (MFRs) have been implicated in the receptor-mediated
uptake of reduced folate cofactors and folate-based chemotherapeutic drugs. We have …

Intracortical brain-computer interfaces (iBCIs) allow people with paralysis to directly control
assistive devices using neural activity associated with the intent to move. Realizing the full …

Department of Biochemistry and Molecular Biology, Medical College of Ohio, PO Box 10008,
Toledo, Ohio 43699-0008, Department of Pharmaceutical Sciences, Medical University of …

A series of 5-arylethyl-, 5-arylthio-, and 5-arylthiomethyl-2, 4-diaminoquinazolines and
related compounds was prepared and evaluated forantimalarial activity against Plasmodium …

In a search for new methods for preparing 2,4‐diaminoquinazolines having a diversity of
substituents in the benzenoid ring, it was found that the reaction of 2,6‐difluorobenzonitrile with …

Hydroxamic acids have been found to exert a number of diverse pharmacologic actions
including antitubercu-lous, antifungal, and antileukemic activities. 2 In addi-tion, certain …

inhibitors are binding in the same way to the same site on the enzyme. The fact that less than
12% of the variance is unaccounted for by eq 1 indicates that a variety of binding modes …

… An alternate and completely different interpretation of this experiment has been proposed
by Nesbitt & Hynes (58), Wilson and co-workers (57, 59), and later by Adelman and co-workers …

Three groups of quinazoline analogues of folic acid were studied as inhibitors of thymidylate
synthetase (TMP synthetase) from L. casei and the mouse leukemia cell line, L1210. …