A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients

TW Flaig, DL Gustafson, LJ Su, JA Zirrolli… - Investigational new …, 2007 - Springer
Silibinin is a polyphenolic flavonoid isolated from milk thistle with anti-neoplastic activity in
several in vitro and in vivo models of cancer, including prostate cancer. Silybin-phytosome is …

General anesthetics potentiate gamma-aminobutyric acid actions on gamma-aminobutyric acidA receptors expressed by Xenopus oocytes: lack of involvement of …

LH Lin, LL Chen, JA Zirrolli, RA Harris - Journal of Pharmacology and …, 1992 - ASPET
Potentiation of the gamma-aminobutyric acid (GABAA) receptor-gated Cl- channel response
has been suggested to be a primary action of some anesthetic agents. We asked whether …

Low‐energy fast atom bombardment tandem mass spectrometry of monohydroxy substituted unsaturated fatty acids

P Wheelan, JA Zirrolli… - Biological mass …, 1993 - Wiley Online Library
The low‐energy collision‐induced dissociation (CID) of the carboxylate anions generated
by fast atom bombardment ionization of monohydroxy unsaturated fatty acids derived from …

Electrospray ionization and low energy tandem mass spectrometry of polyhydroxy unsaturated fatty acids

P Wheelan, JA Zirrolli, RC Murphy - Journal of the American Society for …, 1996 - Springer
Negative ion electrospray ionization, fast-atom bombardment, and low energy tandem mass
spectrometry were used for the analysis of dihydroxy-eicosatrienoic acids, which contain a …

Analysis of docetaxel pharmacokinetics in humans with the inclusion of later sampling time-points afforded by the use of a sensitive tandem LCMS assay

DL Gustafson, ME Long, JA Zirrolli, MW Duncan… - Cancer chemotherapy …, 2003 - Springer
Purpose Docetaxel is a semisynthetic taxane derived from the needles of the European yew
(Taxus baccata) and it is an important chemotherapeutic agent in the treatment of recurrent …

Low-energy tandem mass spectrometry of the molecular ion derived from fatty acid methyl esters: a novel method for analysis of branched-chain fatty acids

JA Zirrolli, RC Murphy - Journal of the American Society for Mass …, 1993 - Springer
Low-energy collision-induced dissociation (CID) of the molecular ions of fatty acid methyl
esters obtained by electron ionization (70 eV) decompose in the tandem quadrupole mass …

12 (R)-hydroxyeicosatrienoic acid: a vasodilator cytochrome P-450-dependent arachidonate metabolite from the bovine corneal epithelium.

…, JR Falck, S Lumin, P Yadagiri, JA Zirrolli… - Journal of Biological …, 1988 - ASBMB
When corneal microsomes were incubated with arachidonic acid in the presence of an
NADPH-generating system, two biologically active metabolites of arachidonic acid were formed. …

Analysis of hydroxy fatty acids as pentafluorobenzyl ester, trimethylsilyl ether derivatives by electron ionization gas chromatography/mass spectrometry

P Wheelan, JA Zirrolli, RC Murphy - Journal of the American Society for …, 1995 - Springer
Electron ionization (EI) gas chromatography/mass spectrometry (GC/MS) analysis of
pentafluorobenzyl ester-trimethyl sllyl ether (PFB-TMS) derivatives of hydroxy-subshtuted fatty acids …

Rapid and sensitive LC/MS/MS analysis of the novel tyrosine kinase inhibitor ZD6474 in mouse plasma and tissues

JA Zirrolli, EL Bradshaw, ME Long… - Journal of pharmaceutical …, 2005 - Elsevier
ZD6474 (N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]
quinazolin-4-amine) is a tyrosine kinase inhibitor with anti-angiogenic and anti-tumor activity that is …

Negative ion electrospray tandem mass spectrometric structural characterization of leukotriene B4 (LTB4) and LTB4-derived metabolites

P Wheelan, JA Zirrolli, RC Murphy - Journal of the American Society for …, 1996 - Springer
The low energy collision induced dissociation (CID) of the carboxylate anions generated by
electrospray ionization of leukotriene B 4 (LTB 4) and 16 of its metabolites was studied in a …