User profiles for I. R. Younis
 | Islam YounisVerified email at gilead.com Cited by 700 |
Effects of tobacco smoking and nicotine on cancer treatment
A substantial number of the world's population continues to smoke tobacco, even in the setting
of a cancer diagnosis. Studies have shown that patients with cancer who have a history of …
of a cancer diagnosis. Studies have shown that patients with cancer who have a history of …
Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review
Methadone is utilized for the treatment of individuals with opiate dependence. Methadone
undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, …
undergoes N-demethylation by multiple cytochrome P450 (CYP) enzymes including CYP3A4, …
Model‐Informed Approaches and Innovative Clinical Trial Design for Adeno‐Associated Viral Vector‐Based Gene Therapy Product Development: A White Paper
…, S Albusaysi, M Burian, IR Younis - Clinical …, 2023 - Wiley Online Library
… (Orcid ID: 0000-0002-1229-7353) Younis Islam, R (Orcid ID: 0000-0001-9000-0431) …
Qosa, H., Hassan, HE, & Younis, IR Overview of clinical pharmacology packages of new drug …
Qosa, H., Hassan, HE, & Younis, IR Overview of clinical pharmacology packages of new drug …
Influence of pH on the dissolution of folic acid supplements
IR Younis, MK Stamatakis, PS Callery… - International journal of …, 2009 - Elsevier
The vitamin folic acid has received considerable attention because of its role in decreasing
the risk of neural tube birth defects, and its potential role in reducing the risks of …
the risk of neural tube birth defects, and its potential role in reducing the risks of …
Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers
Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment
of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work …
of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work …
Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1
Elimination of hydrogen sulfide from glutathione (GSH) converts a well known cellular
nucleophile to an electrophilic species, γ-glutamyldehydroalanylglycine (EdAG). We have found …
nucleophile to an electrophilic species, γ-glutamyldehydroalanylglycine (EdAG). We have found …
Enterohepatic recirculation model of irinotecan (CPT-11) and metabolite pharmacokinetics in patients with glioma
Background Enterohepatic recirculation of irinotecan and one of its metabolites, SN-38, has
been observed in pharmacokinetic data sets from previous studies. A mathematical model …
been observed in pharmacokinetic data sets from previous studies. A mathematical model …
Association of end point definition and randomized clinical trial duration in clinical trials of schizophrenia medications
IR Younis, M Gopalakrishnan, M Mathis… - JAMA …, 2020 - jamanetwork.com
… Conflict of Interest Disclosures: Drs Younis and Mathis contributed to this work while
employees of the US Food and Drug Administration. Dr Younis reported receiving personal fees …
employees of the US Food and Drug Administration. Dr Younis reported receiving personal fees …
Effect of Renal Impairment on the Pharmacokinetics of Firsocostat, an Acetyl‐Coenzyme A Carboxylase Inhibitor, and Cilofexor, a Selective Nonsteroidal Farnesoid X …
E Weber, IR Younis, C Nelson, D Ding… - The Journal of …, 2023 - Wiley Online Library
Firsocostat, a liver‐targeted acetyl‐coenzyme A carboxylase inhibitor, and cilofexor, a
nonsteroidal farnesoid X receptor agonist, are being developed in combination for treatment of …
nonsteroidal farnesoid X receptor agonist, are being developed in combination for treatment of …
Drug‐drug interaction studies of methadone and antiviral drugs: Lessons learned
Different views appear in the literature on the extent of specific cytochrome P450 (CYP)
involvement in methadone metabolism. The aim of this work is to leverage knowledge from drug‐…
involvement in methadone metabolism. The aim of this work is to leverage knowledge from drug‐…