Signalling and pharmacological properties of the P2Y14 receptor

TK Harden, JI Sesma, IP Fricks… - Acta …, 2010 - Wiley Online Library
The P2Y 14 receptor is a relatively broadly expressed G protein‐coupled receptor that is
prominently associated with immune and inflammatory cells as well as with many epithelia. This …

Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor

RL Carter, IP Fricks, MO Barrett, LE Burianek… - Molecular …, 2009 - ASPET
The P2Y 14 receptor was initially identified as a G protein-coupled receptor activated by
UDP-glucose and other nucleotide sugars. We have developed several cell lines that stably …

Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems

IP Fricks, RL Carter, ER Lazarowski… - Journal of Pharmacology …, 2009 - ASPET
Eight G protein-coupled receptors comprise the P2Y receptor family of cell signaling proteins.
The goal of the current study was to define native cell signaling pathways regulated by the …

UDP is a competitive antagonist at the human P2Y14 receptor

IP Fricks, S Maddileti, RL Carter, ER Lazarowski… - … of Pharmacology and …, 2008 - ASPET
G protein-coupled P2Y receptors (P2Y-R) are activated by adenine and uracil nucleotides.
The P2Y 14 receptor (P2Y 14 -R) is activated by at least four naturally occurring UDP sugars, …

Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A3 Adenosine Receptor and Coactivation of the P2Y14 Receptor by a Tethered …

…, K Hong, SM Kilbey, MO Barrett, IP Fricks… - Bioconjugate …, 2010 - ACS Publications
We previously synthesized a series of potent and selective A 3 adenosine receptor (AR)
agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on …

Molecular recognition in the P2Y14 receptor: probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose

H Ko, A Das, RL Carter, IP Fricks, Y Zhou… - Bioorganic & medicinal …, 2009 - Elsevier
The P2Y 14 receptor, a nucleotide signaling protein, is activated by uridine-5′-diphosphoglucose
1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the …

[HTML][HTML] Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats

…, WF Frick, AT Gilbert, DTS Hayman, HS Ip… - PLoS …, 2020 - journals.plos.org
The COVID-19 pandemic highlights the substantial public health, economic, and societal
consequences of virus spillover from a wildlife reservoir. Widespread human transmission of …

Carbohydrate and amino acid metabolism in fasting and aestivating African lungfish (Protopterus dolloi)

NT Frick, JS Bystriansky, YK Ip, SF Chew… - … and Physiology Part A …, 2008 - Elsevier
The potential importance of carbohydrates and amino acids as fuels during periods of fasting
and aestivation in the African lungfish, Protopterus dolloi, were examined. No significant …

Lipid, ketone body and oxidative metabolism in the African lungfish, Protopterus dolloi following 60 days of fasting and aestivation

NT Frick, JS Bystriansky, YK Ip, SF Chew… - … and Physiology Part A …, 2008 - Elsevier
The potential importance of lipids and ketone bodies as fuels in the African lungfish, Protopterus
dolloi, and the role of oxidative metabolism, were examined under control, fasted and …

The crab‐eating frog, Rana cancrivora, up‐regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity

…, L Weng, N Frick, WP Wong, YK Ip - … Zoology Part A …, 2004 - Wiley Online Library
The crab‐eating frog Rana cancrivora is one of only a handful of amphibians worldwide that
tolerate saline waters. They typically inhabit brackish water of mangrove forests of …