Signalling and pharmacological properties of the P2Y14 receptor
TK Harden, JI Sesma, IP Fricks… - Acta …, 2010 - Wiley Online Library
The P2Y 14 receptor is a relatively broadly expressed G protein‐coupled receptor that is
prominently associated with immune and inflammatory cells as well as with many epithelia. This …
prominently associated with immune and inflammatory cells as well as with many epithelia. This …
Quantification of Gi-mediated inhibition of adenylyl cyclase activity reveals that UDP is a potent agonist of the human P2Y14 receptor
RL Carter, IP Fricks, MO Barrett, LE Burianek… - Molecular …, 2009 - ASPET
The P2Y 14 receptor was initially identified as a G protein-coupled receptor activated by
UDP-glucose and other nucleotide sugars. We have developed several cell lines that stably …
UDP-glucose and other nucleotide sugars. We have developed several cell lines that stably …
Gi-dependent cell signaling responses of the human P2Y14 receptor in model cell systems
IP Fricks, RL Carter, ER Lazarowski… - Journal of Pharmacology …, 2009 - ASPET
Eight G protein-coupled receptors comprise the P2Y receptor family of cell signaling proteins.
The goal of the current study was to define native cell signaling pathways regulated by the …
The goal of the current study was to define native cell signaling pathways regulated by the …
UDP is a competitive antagonist at the human P2Y14 receptor
IP Fricks, S Maddileti, RL Carter, ER Lazarowski… - … of Pharmacology and …, 2008 - ASPET
G protein-coupled P2Y receptors (P2Y-R) are activated by adenine and uracil nucleotides.
The P2Y 14 receptor (P2Y 14 -R) is activated by at least four naturally occurring UDP sugars, …
The P2Y 14 receptor (P2Y 14 -R) is activated by at least four naturally occurring UDP sugars, …
Polyamidoamine (PAMAM) Dendrimer Conjugates of “Clickable” Agonists of the A3 Adenosine Receptor and Coactivation of the P2Y14 Receptor by a Tethered …
…, K Hong, SM Kilbey, MO Barrett, IP Fricks… - Bioconjugate …, 2010 - ACS Publications
We previously synthesized a series of potent and selective A 3 adenosine receptor (AR)
agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on …
agonists (North-methanocarba nucleoside 5′-uronamides) containing dialkyne groups on …
Molecular recognition in the P2Y14 receptor: probing the structurally permissive terminal sugar moiety of uridine-5′-diphosphoglucose
H Ko, A Das, RL Carter, IP Fricks, Y Zhou… - Bioorganic & medicinal …, 2009 - Elsevier
The P2Y 14 receptor, a nucleotide signaling protein, is activated by uridine-5′-diphosphoglucose
1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the …
1 and other uracil nucleotides. We have determined that the glucose moiety of 1 is the …
[HTML][HTML] Possibility for reverse zoonotic transmission of SARS-CoV-2 to free-ranging wildlife: A case study of bats
The COVID-19 pandemic highlights the substantial public health, economic, and societal
consequences of virus spillover from a wildlife reservoir. Widespread human transmission of …
consequences of virus spillover from a wildlife reservoir. Widespread human transmission of …
Carbohydrate and amino acid metabolism in fasting and aestivating African lungfish (Protopterus dolloi)
The potential importance of carbohydrates and amino acids as fuels during periods of fasting
and aestivation in the African lungfish, Protopterus dolloi, were examined. No significant …
and aestivation in the African lungfish, Protopterus dolloi, were examined. No significant …
Lipid, ketone body and oxidative metabolism in the African lungfish, Protopterus dolloi following 60 days of fasting and aestivation
The potential importance of lipids and ketone bodies as fuels in the African lungfish, Protopterus
dolloi, and the role of oxidative metabolism, were examined under control, fasted and …
dolloi, and the role of oxidative metabolism, were examined under control, fasted and …
The crab‐eating frog, Rana cancrivora, up‐regulates hepatic carbamoyl phosphate synthetase I activity and tissue osmolyte levels in response to increased salinity
…, L Weng, N Frick, WP Wong, YK Ip - … Zoology Part A …, 2004 - Wiley Online Library
The crab‐eating frog Rana cancrivora is one of only a handful of amphibians worldwide that
tolerate saline waters. They typically inhabit brackish water of mangrove forests of …
tolerate saline waters. They typically inhabit brackish water of mangrove forests of …