… cell counts, blood and nasal eosinophils, T H 1/T H 2 ratio, and measurement of interleukin 4
(IL-4… The T H 1/T H 2 ratio decreased during the allergen season but not significantly in both …

Airway epithelial cells are the first line of defense against the constituents of the inhaled air,
which include allergens, pathogens, pollutants, and toxic compounds. The epithelium not …

… Author links open overlay panel Harissios Vliagoftis MD , Alexandra S. Worobec MD ,
Dean D. Metcalfe MD … H Nagata, AS Worobec, CK Oh, BA Chowdhury, S Tannenbaum, Y …

Under physiological conditions, skin mast cells preferentially localize around nerves, blood
vessels and hair follicles. This observation, which dates back to Paul Ehrlich, intuitively …

Mast cells have been studied extensively for their involvement in allergic reactions, where
they secrete numerous powerful mediators in response to immunoglobulin E and specific …

Background: Matrix metalloproteinases (MMPs) digest extracellular matrix components and
might be important mediators of tissue remodeling. Proteinase activated receptor-2 (PAR-2) …

The human mast cell line (HMC)‐1 cell line is growth‐factor independent because of a
constitutive activity of the receptor tyrosine kinase Kit. Such deregulated Kit activity has also been …

Our current recommendations for diagnosing and treating primary mast cell (MC) activation
syndrome make use of the latest studies and consensus guidelines for clinically recognizing …

… H 1 and H 2 receptor blockers; 3 days for anti-allergic ophthalmic treatments; 48 hrs for
decongestants; 24 hrs for saline nasal sprays or ocular drops. Participants were also excluded if …

… Deb R, Shakib F, Reid K, Clark H. Major house dust mite allergens Dermatophagoides …
Miike S, Kita H. Human eosinophils are activated by cysteine proteases and release …