Physical stability of size controlled small unilameller liposomes coated with a modified polyvinyl alcohol
…, H Yamamoto, T Toyoda, H Toyobuku… - International journal of …, 1998 - Elsevier
The purpose of this work is to evaluate the improvement in physical stability of polymer coated
liposomes. Small unilamellar liposomes (dimilistoylphosphatidylcholine (DMPC): dicetyl …
liposomes. Small unilamellar liposomes (dimilistoylphosphatidylcholine (DMPC): dicetyl …
Development and preclinical efficacy of novel transforming growth factor-β1 short interfering RNAs for pulmonary fibrosis
…, A Fukuda, T Hasegawa, H Toyobuku… - American journal of …, 2012 - atsjournals.org
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No
therapy is currently available. A growing body of evidence supports the role of transforming …
therapy is currently available. A growing body of evidence supports the role of transforming …
Limited influence of P‐glycoprotein on small‐intestinal absorption of cilostazol, a high absorptive permeability drug
H Toyobuku, I Tamai, K Ueno, A Tsuji - Journal of pharmaceutical sciences, 2003 - Elsevier
… replaced with medium containing a test compound and the cells were grown for 24 h. … [ 3
H]daunomycin transport were not observed in LLC‐PK1 cells. The cellular accumulation of [ 3 H]…
H]daunomycin transport were not observed in LLC‐PK1 cells. The cellular accumulation of [ 3 H]…
Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton‐releasing polymer
T Nozawa, H Toyobuku, D Kobayashi, K Kuruma… - Journal of …, 2003 - Elsevier
Utilization of carrier‐mediated transport systems in the gastrointestinal tract to increase the
bioavailability of drugs is of great interest. In the present study, an increased supply of the …
bioavailability of drugs is of great interest. In the present study, an increased supply of the …
Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1
H Toyobuku, Y Sai, I Tamai, A Tsuji - Journal of Pharmacology and …, 2002 - ASPET
… In vitro uptake ofl-[ 3 H]carnosine was determined in HepG2 and WIFB9 … 3 H]carnosine in
mouse liver was evaluated after transduction of AdhPEPT1-EYFP. At pH 6.0, the uptake ofl-[ 3 H…
mouse liver was evaluated after transduction of AdhPEPT1-EYFP. At pH 6.0, the uptake ofl-[ 3 H…
Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier
H Toyobuku, Y Sai, T Kagami, I Tamai, A Tsuji - Journal of Pharmacology …, 2003 - ASPET
The feasibility of using adenovirus-mediated human oligopeptide transporter (hPEPT1) gene
transfer to achieve peptide drug delivery to the brain across the blood-brain barrier was …
transfer to achieve peptide drug delivery to the brain across the blood-brain barrier was …
[CITATION][C] Sustained release liposome for pulmonary drug delivery
…, M Murata, Y Tozuka, H Toyobuku, H Takeuchi
[CITATION][C] Improved stability of doxorubicin-loaded liposomes by polymer coating
H Takeuchi, T Toyoda, H Toyobuku, H Yamamoto… - Proc Int Symp Control Rel …, 1996
[CITATION][C] Otsuka Pharmaceutical Co
H Takeuti, K Hakaho, H Toyobuku - Ltd., Transpulmonary liposome for controlling …, 2013
[CITATION][C] ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION-Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous …
H Toyobuku, Y Sai, T Kagami… - Journal of …, 2003 - Baltimore: Williams & Wilkins, 1909-