When a cell dies in vivo, the event does not go unnoticed. The host has evolved mechanisms
to detect the death of cells and rapidly investigate the nature of their demise. If cell death is …

When cells die in vivo, they trigger an inflammatory response. The ensuing hyperemia, leak
of plasma proteins, and recruitment of leukocytes serve a number of useful functions in host …

… Interestingly, there is emerging evidence that one of these is uric acid (H. Kono, CJ. Chen,
F. … of uric acid from purine catabolism and can even continue to generate it after death (H. …

… g, Unprimed mouse macrophages were incubated for 24 h … appeared as early as 1 h after
incubation with oxidized LDL (not … Indeed, after 24 h of incubation we observed a spontaneous …

… for 3 h with LPS and then left unstimulated or stimulated for 6 h with silica crystals, MSU
crystals or ATP or transfected with poly(dA:dT). Data (error bars, sd) are from one representative …

… (G and H) Multiplexed IHC were compared according to the sites of lesions of advanced
NSCLC patients. Representative pictures (G) of multiplexed IHC of primary and liver metastatic …

… ) Neutrophil numbers in peritoneal exudate cells (PEC) of normal C57BL/6 mice and mice
deficient for Tlr1 (a), Tlr2 (b), Tlr3 (c), Tlr4 (d), Tlr6 (e), Tlr7 (f), Tlr9 (g) or Tlr11 (h) 16 h after ip …

Objective To develop and validate revised classification criteria for granulomatosis with
polyangiitis (GPA). Methods Patients with vasculitis or comparator diseases were recruited into …

Objective To develop and validate revised classification criteria for eosinophilic granulomatosis
with polyangiitis (EGPA). Methods Patients with vasculitis or comparator diseases were …

Objective To develop and validate classification criteria for microscopic polyangiitis (MPA).
Methods Patients with vasculitis or comparator diseases were recruited into an international …