Purpose. The aim of this study was to evaluate the ability of long-circulating PEGylated
cyanoacrylate nanoparticles to diffuse into the brain tissue. Methods. Biodistribution profiles and …

Poly(methoxypolyethyleneglycol cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA)
nanoparticles have demonstrated their capacity to diffuse through the blood-brain barrier …

… b, After 24 h, 48 h and 72 h and up to 28 days post-trauma, the animals were functionally
graded using the Basso, Beattie and Bresnahan grading scale (data presented as mean ± sem, …

The aim of the present study was to evaluate the tumor accumulation of radiolabeled long-circulating
poly(ethylene glycol) (PEG)-coated hexadecylcyanoacrylate nanospheres and non-…

… about 80 000 V h as follows: 500 V for 1 h, 1000 V for 1 h, and 8000 V for 10 h. The gels were
… Then blots were rinsed and incubated with apolipoprotein specific antisera for 3 h at room …

… IEF was carried out for about 80 000 V?h as follows: 500 V for 1 h, 1000 V for 1 h and 8000
V for 10 h. The gels were incubated for 15 min with equilibration buffer 1 (50 mM Tris-HCl, pH …

… up by PBMC, accumulating within cells over 24 h of incubation probably by active, energy-…
of 7 wt% were outgassed at 70 C under secondary vacuum for 8 h prior to measurement. …

… The mice had free access to standard laboratory food and water and were kept on a 12 h
light-dark cycle at 22 ± 1 ◦ C. They were housed under these conditions for at least 5 days …

We have designed an amphiphilic prodrug of gemcitabine (dFdC) by its covalent coupling
to a derivative of squalene, a natural lipid. The resulting bioconjugate self-assembled …

The aim of this study was to design a new antisense oligonucleotide (ON) carrier system
based on alginate nanoparticles and to investigate its ability to protect ON from degradation in …