[HTML][HTML] Absence or pharmacological blocking of placental P-glycoprotein profoundly increases fetal drug exposure

…, O van Tellingen, HR Wiltshire… - The Journal of …, 1999 - Am Soc Clin Investig
… One hour after intravenous paclitaxel administration (10 mg/kg) to pregnant Mdr1a +/– /1b
+/… The paclitaxel ratios in wild-type and heterozygous fetuses were similar 1 hour after drug …

Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs

…, JW Smit, KML Crommentuyn, N Zelcer, HR Wiltshire… - Aids, 2002 - journals.lww.com
Background: Various drug transporters of the ATP-binding cassette (ABC) family restrict the
oral bioavailability and cellular, brain, testis, cerebrospinal fluid and fetal penetration of …

A placebo-and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS …

HR Wiltshire, GJ Kilpatrick, GS Tilbrook… - Anesthesia & …, 2012 - journals.lww.com
… various times between 1 minute and 4 hours postdose and venous samples were collected
between 2 and 12 hours postdose 2 ; there was a period of overlap at the 2-, 3-, and 4-hour

P-glycoprotein limits oral availability, brain, and fetal penetration of saquinavir even with high doses of ritonavir

MT Huisman, JW Smit, HR Wiltshire… - Molecular …, 2001 - ASPET
… Cells were incubated at 37C in 5% CO 2 and 50-μL aliquots were taken each hour, up to 4
h. The … Inulin leakage was tolerated up to one percent per hour per well. The percentage of …

The disposition of saquinavir in normal and P-glycoprotein deficient mice, rats, and in cultured cells

CB Washington, HR Wiltshire, M Man, T Moy… - Drug metabolism and …, 2000 - ASPET
Protease inhibitors are very effective in treating patients infected with HIV. However, many
drugs in this class penetrate poorly into the central nervous system (CNS) and may permit this …

Assessing safety and efficacy of directed P-glycoprotein inhibition to improve the pharmacokinetic properties of saquinavir coadministered with ritonavir

MT Huisman, JW Smit, HR Wiltshire, JH Beijnen… - … of Pharmacology and …, 2003 - ASPET
… Subsequently, we determined the [ 14 C]saquinavir plasma concentration every hour up
to 11 h. Note that we demonstrated previously that even a ritonavir dose of 50 mg kg −1 does …

Biosynthesis. Part XXII. The origin of chelidonine and of other alkaloids derived from the tetrahydroprotoberberine skeleton

AR Battersby, J Staunton, HR Wiltshire… - Journal of the …, 1975 - pubs.rsc.org
The major benzophenanthridine alkaloid chelidonine (14) is shown to be biosynthesised in
Chelidonium majus plants from (S)-reticuline (2)via(S)-scoulerine (4) and (S)-stylopine (7), …

Metabolism of the calcium antagonist, mibefradil (POSICORTM, Ro 40-5967). Part III. Comparative pharmacokinetics of mibefradil and its major metabolites in rat …

HR Wiltshire, BM Sutton, G Heeps, AM Betty… - Xenobiotica, 1997 - Taylor & Francis
1. The metabolism of mibefradil has been examined in rat, marmoset, cynomolgus monkey
and man after single and multiple oral administration. 2. Metabolites typically represent …

Studies of enzyme-mediated reactions. Part II. Stereochemistry of the elimination of ammonia from L-tyrosine catalysed by the enzyme from maize

PG Strange, J Staunton, HR Wiltshire… - Journal of the …, 1972 - pubs.rsc.org
A stereoselective synthesis has been used to yield two samples of (2RS)-tyrosine (DL-tyrosine)
in which the (2S)-form of one carries a (3R)-[3-3H1] label and that of the other, a (3S)-[3-…

Exact solution to the averaging problem in cosmology

DL Wiltshire - Physical Review Letters, 2007 - APS
… We define hr t … While the initial conditions of the CMB require that hr ! 1 at last scattering,
for observationally relevant initial conditions, the general solution (11) and (13) approaches the …