4-Amino [1, 2, 4] triazolo [4, 3-a] quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants

R Sarges, HR Howard, RG Browne… - Journal of medicinal …, 1990 - ACS Publications
A series of 4-amino [l, 2, 4] triazolo [4, 3-a] quinoxalines has been prepared. Many compounds
from this class reduce immobility inPorsolt’s behavioral despair model in rats upon acute …

[PDF][PDF] Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity.

…, S McLean, V Guanowsky, HR Howard… - … of Pharmacology and …, 1995 - Citeseer
ABBREVIATIONS: DA, dopamine; EPS, extrapyramidal side effects; 5-HT, 5-hydroxytryptamine(serotonin);
CHO, Chinese hamster ovary; Gpp [NH] p, 5’-guanylyl-imidodiphosphate; …

Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile

AW Schmidt, LA Lebel, HR Howard Jr… - European journal of …, 2001 - Elsevier
Ziprasidone is a novel antipsychotic agent with a unique combination of pharmacological
activities at human receptors. Ziprasidone has high affinity for human 5-HT receptors and for …

Predicting USCS soil classification from soil property variables using Random Forest

DR Gambill, WA Wall, AJ Fulton, HR Howard - Journal of Terramechanics, 2016 - Elsevier
Soil classification systems are widely used for quickly and easily summarizing soil properties
and provide a shorthand method of communication between scientists, engineers, and end-…

3-Benzisothiazolylpiperazine derivatives as potential atypical antipsychotic agents

HR Howard, JA Lowe, TF Seeger… - Journal of medicinal …, 1996 - ACS Publications
A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating
potent D 2 and 5-HT 2A antagonist activity was investigated as an approach to a novel …

The energy and environmental implications of UK more electric transition pathways: A whole systems perspective

GP Hammond, HR Howard, CI Jones - Energy Policy, 2013 - Elsevier
Electricity generation contributes a large proportion of the total greenhouse gas emissions
in the United Kingdom (UK), due to the predominant use of fossil fuel (coal and natural gas) …

Expert outpatient burn care in the home through mobile health technology

DI Garcia, HR Howard, RA Cina, S Patel… - Journal of Burn Care …, 2018 - academic.oup.com
Access to care for pediatric burns remsains a major public health problem in the United
States. Telemedicine has an opportunity to improve access to care, but current models are …

A novel class of" GABAergic" agents: 1-aryl-3-(aminoalkylidene) oxindoles

R Sarges, HR Howard, BK Koe… - Journal of medicinal …, 1989 - ACS Publications
Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic
mechanism, was observed in a series of l-aryl-3-(aminoalkylidene) oxindoles. Optimal MPA …

Evaluation of compost blankets for erosion control from disturbed lands

R Bhattarai, PK Kalita, S Yatsu, HR Howard… - Journal of …, 2011 - Elsevier
… The station measured rainfall using tipping bucket with an accuracy of ±1.0% at 1 inch
per hour. The rainfall data obtained from weather station was also verified with rainfall data …

The 20% house–An integrated assessment of options for reducing net carbon emissions from existing UK houses

…, SJG Cooper, Á O'Grady, MC McManus, HR Howard… - Applied Energy, 2015 - Elsevier
This paper takes an integrated analysis approach to explore the options available for a UK
homeowner to reduce their domestic emissions to the level advised by the UK governments …