Pharmacological mechanisms in cocaine's cardiovascular effects

CW Schindler, SR Tella, HK Erzouki… - Drug and alcohol …, 1995 - Elsevier
… More recently we have also begun to investigate the direct effects of the cocaine metabolites
on the cardiovascular system (Erzouki et al., 1993a,b). As these studies were directed …

Sympathetic nervous system mediated cardiovascular effects of cocaine are primarily due to a peripheral site of action of the drug

RA Gillis, YM Hernandez, HK Erzouki… - Drug and alcohol …, 1995 - Elsevier
… The dose of cocaine chosen for our study in dogs was 0.25 mg/kg, iv (Erzouki, 1991). Our
rationale for using this dose is that it is in the same range of doses shown in studies in humans …

Effects of cocaine, cocaine metabolites and cocaine pyrolysis products on the hindbrain cardiac and respiratory centers of the rabbit ag

HK Erzouki, AC Allen, AH Newman, SR Goldberg… - Life sciences, 1995 - Elsevier
Hemodynamic and respiratory effects of vertebral artery or iv administration of cocaine,
cocaine metabolites and cocaine pyrolysis products were measured in anesthetized rabbits. …

Comparison of the effects of cocaine and its metabolites on cardiovascular function in anesthetized rats

HK Erzouki, I Baum, SR Goldberg… - Journal of …, 1993 - journals.lww.com
Hemodynamic and cardiac-electrophysiologic effects of cocaine and its metabolites were
measured in 18 groups (n= 6 each) of anesthetized, artificially ventilated rats during …

Cocaine acts in the central nervous system to inhibit sympathetic neural activity.

VF Raczkowski, YM Hernandez, HK Erzouki… - … of Pharmacology and …, 1991 - ASPET
Cocaine was administered iv to decerebrate cats while monitoring cardiac preganglionic
sympathetic nerve activity (SNA), arterial blood pressure (BP) and heart rate (HR). Cocaine, 4 …

[PDF][PDF] Role of the sympathetic nervous system in the cardiovascular effects of cocaine

…, KL Dretchen, HK Erzouki… - … Toxicity of Cocaine …, 1991 - archives.nida.nih.gov
Many of the cardiovascular effects of cocaine have been attributed to sympathomimetic actions
of the drug. The peripheral nervous system and the brain have been studied as potential …

Sites and mechanisms responsible for the cardiovascular effects of cocaine.

HK Erzouki - 1992 - elibrary.ru
The purpose of this research was to (1) test the hypothesis that cocaine elicits cardiovascular
effects by increasing central sympathetic outflow,(2) evaluate the effects of cocaine on the …

Comparison of cocaine and Na+ channel blockers on cardio-respiratory function in the rabbit

HK Erzouki, SR Goldberg, CW Schindler - European journal of …, 1999 - Elsevier
The cardio-respiratory effects of cocaine were compared to various Na + channel blocking
Class I antiarrhythmics. Anesthetized rabbits were treated with various doses of either cocaine…

[HTML][HTML] Role of the Sympathetic Nervous System in the Cardiovascular Effects of Cocaine Richard A. Gillis, Lisa C. Bachenheimer, Kenneth L. Dretchen

HK Erzouki, YM Hernandez, RK Jain… - NIDA Research …, 1976 - books.google.com
Many of the cardiovascular effects of cocaine have been attributed to sympathomimetic actions
of the drug. The peripheral nervous system and the brain have been studied as potential …

Cardiorespiratory Effects of Cocaine-Heroin Combinations in the Anesthetized Rabbit

HK Erzouki, SR Goldberg… - NIDA RESEARCH …, 1995 - scholar.archive.org
Co-administration of cocaine (COC) and heroin (HE) is a common practice among drug
abusers. It is generally accepted that cocaine is a cardiorespiratory stimulant, while heroin is a …