Molecular mechanisms and regulation of opioid receptor signaling

PY Law, YH Wong, HH Loh - Annual review of pharmacology …, 2000 - annualreviews.org
… of all the Ser and Thr within the carboxyl tail to Ala resulted in a mutant μ-opioid receptor
that was not phosphorylated in the presence of DAMGO (Maestri-El-Kouhen, PY Law, HH Loh, …

Regulation of opioid receptor activities

PY Law, HH Loh - Journal of Pharmacology and Experimental …, 1999 - ASPET
From the demonstration of the existence of multiple opioid receptors and the isolation of the
endogenous opioid peptides in the brain, it is now clear that the activities of these receptors …

Effects of opioids on the immune system

S Roy, HH Loh - Neurochemical research, 1996 - Springer
Both therapeutic and chronic uses of opioids compromise the optimal functioning of the
immune system. Overwhelming evidence suggests that opioid use affects both innate immunity …

Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord

…, JH Lee, AH Nakano, RJ Dado, HH Loh… - Journal of …, 1995 - Soc Neuroscience
Opioid receptors regulate neuronal activity by both pre- and postsynaptic mechanisms. We
recently reported that the cloned delta- opioid receptor (DOR1) is primarily targeted to axons, …

beta-endorphin is a potent analgesic agent.

HH Loh, LF Tseng, E Wei, CH Li - Proceedings of the …, 1976 - National Acad Sciences
beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is
administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in …

μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

HH Loh, HC Liu, A Cavalli, W Yang, YF Chen… - Molecular Brain …, 1998 - Elsevier
The μ opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In
these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-…

[HTML][HTML] Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

…, S Kim, FF Tsai, QF Li, J Jeffry, JY Kim, HH Loh… - Cell, 2011 - cell.com
Spinal opioid-induced itch, a prevalent side effect of pain management, has been proposed
to result from pain inhibition. We now report that the μ-opioid receptor (MOR) isoform …

delta-Opioid receptor immunoreactivity: distribution in brainstem and spinal cord, and relationship to biogenic amines and enkephalin

…, M Riedl, JH Lee, PY Law, HH Loh… - Journal of …, 1995 - Soc Neuroscience
We have recently developed antisera which recognize epitopes of the cloned delta-opioid
receptor (DOR; Dado et al., 1993). In the present report we have further characterized these …

β-Arrestin-dependent μ-opioid receptor-activated extracellular signal-regulated kinases (ERKs) translocate to nucleus in contrast to G protein-dependent ERK …

H Zheng, HH Loh, PY Law - Molecular pharmacology, 2008 - ASPET
The cellular location of extracellular signal-regulated kinases (ERKs) activated by a G
protein-coupled receptor was shown to be dependent on the pathway that mediated their activation…

Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of μ-and δ-but not κ-opioids

CL Marker, R Luján, HH Loh… - Journal of …, 2005 - Soc Neuroscience
Opioids can evoke analgesia by inhibiting neuronal targets in either the brain or spinal cord,
and multiple presynaptic and postsynaptic inhibitory mechanisms have been implicated. …