… By applying this approach on intact plated recombinant cell lines expressing the human G
protein coupled receptors of interest, we have already detected such rebinding behaviour for …

Exploring avidity: understanding the potential gains in functional affinity and target
residence time of bivalent and heterobivalent ligands - Vauquelin - 2013 - British Journal of …

… G protein-dependent effects on blood pressure (via inositol triphosphate production, cytosolic
calcium transients and vascular smooth muscle contraction), there are also long-term G …

Both [ 3 H]clonidine and [ 3 H]idazoxan bind to α 2 adrenoceptors. The former also labels
imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to …

The fruit and the leaves of Annona muricata (Annonaceae) are used in traditional medicine
for their tranquillizing and sedative properties. Extracts of the plant have been shown to …

… Interestingly, the occupancy curves remain exactly the same as those shown in Figure 2G
when both k off and k on are changed alike to yield an iso-K D situation in simulations that are …

CHO‐K1 cells that were stably transfected with the gene for the human AT 1 receptor (CHO‐AT
1 cells) were used for pharmacological studies of non‐peptide AT 1 receptor antagonists. …

A deficiency of dopamine in the striatum may contribute to the decline in motor function
associated with aging. We examined the effect of aging on the densities of the D 1 and D 2 …

… protein-coupled receptors (GPCRs) can trigger an increase in cytosolic calcium concentration,
most commonly by initiating a cascade of events involving G proteins, phospholipase C (…

Importance of the field: It is well established that the in vivo duration of drug action not only
depends on macroscopic pharmacokinetic properties like its plasma half-life, but also on the …