Neuropeptide S is a stimulatory anxiolytic agent: a behavioural study in mice
A Rizzi, R Vergura, G Marzola, C Ruzza… - British journal of …, 2008 - Wiley Online Library
Background and purpose: Neuropeptide S (NPS) was recently identified as the endogenous
ligand of an orphan receptor, now referred to as the NPS receptor. In vivo, NPS produces a …
ligand of an orphan receptor, now referred to as the NPS receptor. In vivo, NPS produces a …
[Nphe1,Arg14,Lys15]Nociceptin‐NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor
…, R Bigoni, R Guerrini, G Marzola… - British journal of …, 2002 - Wiley Online Library
Nociceptin/orphanin FQ (N/OFQ) modulates several biological functions by activating a specific
G‐protein coupled receptor (NOP). Few molecules are available that selectively activate …
G‐protein coupled receptor (NOP). Few molecules are available that selectively activate …
Blockade of nociceptin/orphanin FQ–NOP receptor signalling produces antidepressant‐like effects: pharmacological and genetic evidences from the mouse forced …
EC Gavioli, G Marzola, R Guerrini… - European Journal of …, 2003 - Wiley Online Library
Nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor, regulates
several central functions such as pain transmission, learning and memory, fear and anxiety and …
several central functions such as pain transmission, learning and memory, fear and anxiety and …
Characterization of [Nphe1]nociceptin(1‐13)NH2, a new selective nociceptin receptor antagonist
…, R Guerrini, R Bigoni, A Rizzi, G Marzola… - British journal of …, 2000 - Wiley Online Library
Nociceptin (orphanin FQ) is a novel neuropeptide capable of inducing a variety of biological
actions via activation of a specific G‐protein coupled receptor. However, the lack of a …
actions via activation of a specific G‐protein coupled receptor. However, the lack of a …
Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice
EC Gavioli, CW Vaughan, G Marzola, R Guerrini… - Naunyn-Schmiedeberg's …, 2004 - Springer
Receptor antagonist and knockout studies have demonstrated that blockade of signalling
via nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) has antidepressant-like effects in …
via nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) has antidepressant-like effects in …
Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(–)-cis-1-methyl-7-[[4-(2, 6-dichlorophenyl) piperidin-1-yl] methyl]-6, 7 …
A Rizzi, EC Gavioli, G Marzola, B Spagnolo… - … of Pharmacology and …, 2007 - ASPET
… Male Swiss albino and CD1/C57BL6/J-129 NOP +/+ and NOP –/– mice weighing 25 to
30 g were used. These later animals were obtained by backcrossing hybrid C57BL6/J-129 (Nishi …
30 g were used. These later animals were obtained by backcrossing hybrid C57BL6/J-129 (Nishi …
Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay
G Calo, A Rizzi, G Marzola, R Guerrini… - British journal of …, 1998 - Wiley Online Library
… NC receptor(s) which mediates these effects, using some NC receptor agonists (NC, NCNH
2 , NC(1–13)NH 2 and NC(1–9)NH 2 ) and the newly discovered NC receptor antagonist [F/G…
2 , NC(1–13)NH 2 and NC(1–9)NH 2 ) and the newly discovered NC receptor antagonist [F/G…
In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor
…, RD Wainford, C Fischetti, R Guerrini, G Marzola… - Peptides, 2007 - Elsevier
… Male Sprague-Dawley rats (Harlan, Indianapolis, IN) weighing 300–350 g were used for the
… Food intake was measured after 30 and 60 min from drug injection and expressed as g/kg …
… Food intake was measured after 30 and 60 min from drug injection and expressed as g/kg …
Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies
A Rizzi, S Molinari, M Marti, G Marzola - Neuropharmacology, 2011 - Elsevier
… The average body weight of NOP(+/+) and NOP(−/−) rats was 300 ± 9 and 288 ± 11 g
respectively on arrival in our animal facility, and 384 ± 9 and 374 ± 9 g respectively before …
respectively on arrival in our animal facility, and 384 ± 9 and 374 ± 9 g respectively before …
Behavioural phenotypic characterization of CD-1 mice lacking the neuropeptide S receptor
…, A Pulga, A Rizzi, G Marzola, R Guerrini, G Calo - …, 2012 - Elsevier
Neuropeptide S (NPS) is the endogenous ligand of a previously orphan receptor now named
NPSR. In the brain NPS regulates several biological functions including anxiety, arousal, …
NPSR. In the brain NPS regulates several biological functions including anxiety, arousal, …