The introduction of atypical antipsychotics (AAPs) since the discovery of its prototypical drug
clozapine has been a revolutionary pharmacological step for treating psychotic patients as …

The introduction of super‐resolution fluorescence microscopy has allowed the visualization
of single proteins in their biological environment. Recently, these techniques have been …

Evidence for heterodimerization has recently been provided for dopamine D 1 and adenosine
A 1 receptors as well as for dopamine D 2 and somatostatin SSTR 5 receptors. In this …

The repeated finding of an apparent protective effect of cigarette smoking on the risk of
Parkinson's disease is one of the few consistent results in the epidemiology of this disorder. …

Although highly controversial just a few years ago, the idea that G‐protein‐coupled receptors
(GPCRs) may undergo homo‐oligomerization or hetero‐oligomerization has recently …

Apomorphine in combination with a peripheral dopamine receptor blocker (domperidone)
was administered to four parkinsonian patients in a double-blind placebo-controlled study. …

Bromhexine is an over-the-counter mucolytic cough suppressant that was introduced in 1963
under the trademark of Bisolvon®. It is a widely prescribed drug for treatment of a range of …

Norepinephrine (NE) depletion caused by damage to locus ceruleus neurons was shown to
worsen experimental Parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-…

In cynomologus monkeys, systemic administration of MK‐801, a noncompetitive antagonist
for the N‐methyl‐4‐aspartate receptor, prevented the development of the parkinsonian …

The En2 gene, coding for the homeobox-containing transcription factor Engrailed-2 (EN2),
has been associated to autism spectrum disorder (ASD). Due to neuroanatomical and …