… & Tucker, GT Prediction of the clearance of eleven drugs and associated variability in
neonates, … Tucker, GT The rational selection of drug interaction studies: implications of recent …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver), …

The introduction of the new long acting local anaesthetics, bupivacaine and etidocaine, has
stimulated an expansion of interest in regional anaesthesia, particularly for obstetrical …

METFORMIN KINETICS IN HEALTHY SUBJECTS AND IN PATIENTS WITH DIABETES
MELLITUS Page 1 Br. J. clin. Pharmac. (1981), 12, 235-246 METFORMIN KINETICS IN …

Inhibition of human cytochrome P4502D6 (CYP2D6)‐catalysed metabolism can lead to
clinically significant alterations in pharmacokinetics. Since there is evidence that the selective …

Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …

The single-dose pharmacokinetics of amiodarone have been studied in volunteer subjects
given 400 mg doses by the intravenous and oral routes. The data show the compound to …

A diversity of equations is available for the estimation of liver volume (LV), derived from studies
in populations of ethnically homogeneous individuals and using a variety of methods of …

Influence of Dose, Cigarette Smoking, Age, Sex, and Metaboli... : Journal of Clinical
Psychopharmacology Influence of Dose, Cigarette Smoking, Age, Sex, and Metabolic Activity on …

objective The objective of this study was to examine the variables determining hydrocortisone
(HC) disposition in patients with adrenal insufficiency and to develop practical protocols …