NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The
NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery …

… risk of developing overt hypertension [23–25], consistent with the concept that systemic
low-grade inflammation may precede hypertension. Systemic low-grade inflammation can be …

Diverse stimuli, including shear stress, cyclic strain, oxidized LDL, hyperglycemia, and cell
growth, modulate endothelial nitric oxide synthase (eNOS) expression. Although seemingly …

In this study, we defined the signaling cascade responsible for increased eNOS mRNA
expression in response to laminar shear stress. This pathway depends on the tyrosine kinase c-…

The endothelium is essential for the maintenance of vascular homeostasis. Central to this
role is the production of endothelium-derived nitric oxide (EDNO), synthesized by the …

Multi-protein complexes called inflammasomes have recently been identified and shown to
contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-…

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke.
Traditionally, hypertension has been regarded as a disorder of two systems that are involved …

NADPH oxidases (NOXs) are reactive oxygen species (ROS)-generating enzymes implicated
in the pathophysiology of vascular diseases such as hypertension and stroke. Endothelial …

… Dr Drummond is supported by a Peter Doherty Fellowship from the National Health and
Medical Research Council of Australia (007044). Dr Rye is a National Heart Foundation of …

The Nox family NADPH oxidases are reactive oxygen species (ROS)-generating enzymes
that are strongly implicated in atherogenesis. However, no studies have examined which Nox …