… Klaassen & Plaa (104) have also pointed out the possibility that the techniques devised for
the determination of conjugated dienes in vivo might be too insensitive to detect that degree …

During the past 10 years, study of CC14 liver injury has been dominated by two related
ideas:(1) The realization that CC14 toxicity depends on cleavage of the CCI3-C1 bond, and (2) …

Intrahepatic cholestasis is the chemically induced syndrome characterized by biliary retention
without evidence of mechanical obstruction. The drugs known to have caused the disease …

… Klaassen & Plaa (66) found no evidence of the presence of conjugated dienes (a sensitive
in vivo indicator of lipid peroxidation) after administration of chloroform in rats with dosages …

… , using both pentobarbital anesthesia and sulfobromophthalein retention were carried out
with a series of chlorinated, brominated, and iodinated methane derivatives (Kutob and Plaa, …

Chlorinated hydrocarbons differ in their capacity to produce liver damage. The comparative
effects of carbon tetrachloride (CCl 4 ), chloroform, 1,1,1trichloroethane and 1,1,2-…

The “up-and-down” statistical method was used to estimate the LD 50 and liver and kidney
dysfunction ED 50 values in dogs, and serum glutamic-pyruvic transaminase was used to …

This second edition looks at the physiologic, biochemical, and morphologic characteristics
of hepatotoxicity and includes an analysis of techniques in molecular biology and …

Studies that specifically address the influence of controlled human exposure to a combination
of solvents on the biological monitoring of exposure are limited in number. The present …

Cholestasis was established in mice by the administration of a single oral dosage of 150 mg
of α-naphthylisothiocyanate per kilogram and compared to extrahepatic cholestasis effected …