Selective pharmacological inhibition of distinct nitric oxide synthase isoforms

GJ Southan, C Szabó - Biochemical pharmacology, 1996 - Elsevier
Nitric oxide (NO) is produced in physiological and pathophysiological conditions by three
distinct isoforms of NO synthase (NOS): endothelial NOS (ecNOS), inducible NOS (iNOS), and …

Poly (ADP-ribose) polymerase inhibitors

GJ Southan, C Szab - Current medicinal chemistry, 2003 - ingentaconnect.com
Poly(ADP-ribose) polymerase-1 (PARP-1) is the principal member of the PARP enzyme
family consisting of PARP-1 and several recently identified novel poly(ADP-ribosyl)ating …

Diabetic endothelial dysfunction: the role of poly (ADP-ribose) polymerase activation

…, DG Hoyt, KGK Murthy, AL Salzman, GJ Southan… - Nature medicine, 2001 - nature.com
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated
atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here …

Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock

…, L Virág, Z Lohinai, GJ Southan… - The Journal of …, 2000 - journals.aai.org
Extracellular purines, including adenosine and ATP, are potent endogenous
immunomodulatory molecules. Inosine, a degradation product of these purines, can reach high …

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide …

C Szabo, GJ Southan… - Proceedings of the …, 1994 - National Acad Sciences
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms
of NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases, …

Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity

GJ Southan, C Szabó… - British journal of …, 1995 - Wiley Online Library
1 The induction of a calcium‐independent isoform of nitric oxide (NO) synthase (iNOS) and
a subsequent enhanced formation of NO has been implicated in the pathophysiology of a …

Novel phenanthridinone inhibitors of poly (adenosine 5′-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents

…, J VanDuzer, AL Salzman, GJ Southan… - Critical care …, 2002 - journals.lww.com
Objective To synthesize novel inhibitors of the nuclear enzyme poly (adenosine 5′-diphosphate
[ADP]-ribose) synthetase (PARS), also known as poly (ADP-ribose) polymerase (PARP)…

[HTML][HTML] Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage

…, G Ferrer-Sueta, B Zingarelli, GJ Southan… - Journal of Biological …, 1997 - ASBMB
Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for
some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity …

Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor

JE Saavedra, GJ Southan, KM Davies… - Journal of medicinal …, 1996 - ACS Publications
Reaction of nitric oxide (NO) with l-proline in methanolic sodium methoxide yields a
diazeniumdiolate product, C 5 H 7 N 3 O 4 Na 2 ·CH 3 OH (PROLI/NO), that can be stabilized in …

Poly (ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation

…, TJ Dengler, L Liaudet, PG Jagtap, GJ Southan… - Circulation …, 2002 - Am Heart Assoc
The aim of the present study was to investigate the effects of the novel poly(ADP-ribose)
polymerase (PARP) inhibitor PJ34 (N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)-N,N-…