A histochemical method is presented for localizing ChE activity by incubating tissue sections
in a medium containing acetylthiocholine, copper glycinate and copper thiocholine. Results …

The cholinergic nerve fibers, which employ acetylcholine (ACh) as a neurohumoral
transmitter, and the results of their activation are listed. The reactions between the enzyme …

It has become increasingly apparent that diffusion processes play an important role in the
production of artifacts of localization in enzymatic histochemical procedures. False …

A previously described histochemical method for the localization of specific or aeetylcholinesterase
(AChE) and non-specific cholinesterase (ChE) has been modified to increase its …

Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy,
and from the viewpoint of practical significance they are more appropriately classified as …

With the technical advances of the past few decades, there has been increasing emphasis
in neurophysiology and neuropharmacology on studies at the cellular and subcellular levels, …

1. The rates of hydrolysis of several choline esters and their thio-analogues have been studied,
using purified enzymes and homogenates of cat tissue. The effects of DFP, Nu 683 and …

1. Eserine, by combining reversibly with rat brain cholinesterase, has been shown to protect
the enzyme against irreversible inactivation by DFP in vitro. The degree of protection varied …

… U KOELLE, GB: The elimination of diffusion artifacts in the histochemical localization of cho…
li KOELLE, GB: Cholinesterases of the tissues and sera of rabbits, Biochem. J., in the press. …

IT is now just over half a century since Otto Loewi provided the first conclusive evidence of
the humoral, or chemical, transmission of nerve impulses, a concept that had been suggested …