Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member
of ABC drug efflux membrane transporters. It is a 655 amino acid peptide with an ability …

Detailed understanding of the mechanisms employed in transfer of drugs across the placenta
is essential for optimization of pharmacotherapy during pregnancy. Disclosure of drug …

… F. tularensis needs PilF for the biogenesis of Tfp (35); pilF gene inactivation leads to
significant defects in adherence to distinct types of cells and causes loss of virulence in a mouse …

In our study, we tested the hypothesis whether valproic acid (VPA) in therapeutic concentrations
has potential to affect expression of CYP3A4 and MDR1 via constitutive androstane …

… On the other hand, in the rat placenta, we have observed increasing expression of Oct3
towards the end of gestation on both mRNA and protein levels (Ahmadimoghaddam & Staud, …

ATP-binding cassette (ABC) drug efflux transporters limit intracellular concentration of their
substrates by pumping them out of cell through an active, energy dependent mechanism. …

The placenta is the first organ to be created during mammalian development. As the main
link between the mother and the fetus it has more diverse functions than any other organ, …

… The reactions were monitored and the purity of the products was checked by TLC (Silufol UV
254, Kavalier Votice, Czech Republic and Merck TLC plates Silica gel 60 F 254 , aluminium …

… Peak concentrations (Cmax) of mefloquine, an antimalarial drug, were significantly lower
in the pregnant patients and the total apparent volume of distribution (Vd/F) was larger, …

… No statistically significant differences between M>F and F>M clearances were observed at
… in transplacental clearances in both M>F and F>M directions, confirming involvement of a …