α-Pyrrolidinovalerophenone (α-PVP, 7) is an illegal synthetic stimulant that is being sold on
the clandestine market as “flakka” and “gravel”. The potent pharmacological effects of α-PVP …

Regulator of G protein signaling (RGS) proteins are multifunctional proteins expressed in
peripheral and neuronal cells, playing critical roles in development, physiologic processes, …

… unpaired two-tailed t-tests after an F test for variance. Results for behavioral and biochemical
studies are expressed as the mean ± sem F and t values for each dataset and analysis are …

Synthetic cathinones, β-keto analogues of amphetamine (or, more correctly, of phenylalkylamines),
represent a new and growing class of abused substances. Several such analogues …

Background and Purpose Methcathinone ( MCAT ) is a potent monoamine releaser and parent
compound to emerging drugs of abuse including mephedrone (4‐ CH 3 MCAT ), the para…

Methcathinone (MCAT) is a monoamine releaser and parent compound to a new class of
designer drugs that includes the synthetic cathinones mephedrone and flephedrone. Using …

… The right panels (B, D, and F) show the number of stimulations per component collapsed
across all frequencies. Abscissae: Drug dose in mg kg-1. Ordinates: Percentage of baseline …

Background and Purpose There is growing concern over the abuse of certain psychostimulant
methcathinone ( MCAT ) analogues. This study extends an initial quantitative structure–…

Positive allosteric modulators (PAMs) of the μ-opioid receptor (MOR) have been proposed to
exhibit therapeutic potential by maximizing the analgesic properties of clinically used opioid …

Background HDAC6 is a class IIB histone deacetylase expressed at many levels of the
nociceptive pathway. This study tested the ability of novel and selective HDAC6 inhibitors to …