Adenosine is a potent anti-inflammatory mediator. Through elevation of endogenous
adenosine concentrations the adenosine kinase inhibitor GP515 might serve to down-regulate …

The proinflammatory cytokines interleukin (IL)-1β and IL-18 are supposed to play a crucial
role in the pathogenesis of human inflammatory bowel disease. To exert biological activity, …

The two matrix metalloproteinases (MMPs) M r 72,000 type IV collagenase (MMP-2, gelatinase
A) and M r 92,000 type IV collagenase (MMP-9, gelatinase B) play key roles in tissue …

Previously we demonstrated an ameliorating effect of the interleukin-1ß converting enzyme (ICE)
inhibitor pralnacasan on dextran sulfate sodium (DSS)-induced colitis. This study …

Mesopram, a specific inhibitor of type-4 phosphodiesterase, decreases the synthesis of tumor
necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). In the present study, we investigated the …

Zum Thema Klinische Studien aus den vergangenen 5 Jahren belegen die zentrale Rolle
des Tumornekrosefaktors (TNF) im pathophysiologischen Geschehen der rheumatoiden …

B cell chronic lymphocytic leukemia (B-CLL) is an incurable clonal disease which shows
initial responsiveness to a number of chemotherapeutic drugs. However, in most patients the …

The phase transitions occurring during calcination of flame-made calcium phosphates with
Ca/P ratios between 1.00 and 1.54 were investigated by thermal analysis and powder X-ray …

Süſte wälzten. Bald war Alles duntele Nacht, und das Meer nahm die unheimlich ſchwarzgrüne
Farbe an, über welche das weiße Schaumnes hin und her rieſelt in raſt-loſem Gewoge. …

Methylxanthines are commonly recommended as anthropogenic markers, yet possible
diffuse sources are largely unaccounted for. In this study, eight methylxanthines and xanthine …