Structure-activity relationships of amidine derivatives
FN Fastier - Pharmacological Reviews, 1962 - ASPET
The pharmacological actions of amidine [—C(NH 2 ):NH 2 ] derivatives given most attention
in this review are those affecting blood pressure, smooth and skeletal muscle tone, and …
in this review are those affecting blood pressure, smooth and skeletal muscle tone, and …
Stimulation of the human thyroid by infusions of plasma containing LATS protector
DD Adams, FN Fastier, JB Howie… - The Journal of …, 1974 - academic.oup.com
LATS protector was tested for ability to stimulate the human thyroid gland by infusing
plasma containing LATS protector into human volunteers. Infusions of plasma from normal, …
plasma containing LATS protector into human volunteers. Infusions of plasma from normal, …
Mechanism of action of reserpine in producing gastric haemorrhage and erosion in the mouse
…, DS Campion, FN Fastier - British Journal of …, 1959 - Wiley Online Library
Gastric haemorrhage was produced regularly in mice within 6 hours of the subcutaneous
injection of a large dose (2 to 10 mg./kg.) of reserpine or of deserpidine. Rescinnamine, …
injection of a large dose (2 to 10 mg./kg.) of reserpine or of deserpidine. Rescinnamine, …
Prolongation of chloral hydrate sleeping time by 5‐hydroxytryptamine and by certain other drugs
FN Fastier, RN Speden, H Waal - British Journal of …, 1957 - Wiley Online Library
Various drugs have been tested for a capacity to prolong the hypnotic effect of chloral hydrate
in mice. Amongst the compounds which, when injected subcutaneously in substantial …
in mice. Amongst the compounds which, when injected subcutaneously in substantial …
The effect of procaine amide on excitability, refractoriness and conduction in the mammalian heart
H Woske, J Belford, FN Fastier, CMC Brooks - Journal of Pharmacology and …, 1953 - ASPET
1. Procaine amide completely protected the dog heart in situ against electrical induction of
auricular fibrillation. It also produced a marked rise in the threshold for multiple firing and …
auricular fibrillation. It also produced a marked rise in the threshold for multiple firing and …
Modern concepts in relationship between structure and biological activity
FN Fastier - Annual Review of Pharmacology, 1964 - annualreviews.org
One of the pharmacological triumphs of the nineteenth century was the demonstration that
various pure chemicals are effective drugs. The resulting belief that the" virtues" of drugs …
various pure chemicals are effective drugs. The resulting belief that the" virtues" of drugs …
Pharmacological properties of phenyldiguanide and other amidine derivatives in relation to those of 5‐hydroxytryptamine
FN Fastier, MA McDowall… - British Journal of …, 1959 - Wiley Online Library
Cats in which the coronary and allied chemoreflexes could not be obtained with small intravenous
doses of 5‐hydroxytryptamine were insensitive also to phenyldiguanide. In cats which …
doses of 5‐hydroxytryptamine were insensitive also to phenyldiguanide. In cats which …
Reflex actions of some isothiourea derivatives on circulation and respiration
GS Dawes, FN Fastier - British Journal of Pharmacology and …, 1950 - ncbi.nlm.nih.gov
RESULTS All the compounds available were tested in the first instance to see whether they
possessed any activity of the type expected, viz.,(i) the production of a transient fall of blood …
possessed any activity of the type expected, viz.,(i) the production of a transient fall of blood …
Some properties of amarin, with special reference to its use in conjunction with adrenaline for the production of idio-ventricular rhythms
FN Fastier, FH Smirk - The Journal of Physiology, 1948 - ncbi.nlm.nih.gov
… FN FASTIER AND FH SMIRK a comparable rise of blood pressure could be secured with
1/5th or, exceptionally, 1/20th of the amount of adrenaline used before the amarin. The …
1/5th or, exceptionally, 1/20th of the amount of adrenaline used before the amarin. The …
Pharmacological aspects of bunamidine dosing of dogs
FN Fastier - New Zealand Veterinary Journal, 1972 - Taylor & Francis
Extract No doubt you would all be delighted to note when Mr MacIntyre opened this conference
that our Minister of Lands is well aware of the economic loss resulting from disease in …
that our Minister of Lands is well aware of the economic loss resulting from disease in …