Sulfonation has a major function in modulating the biological activities of a wide number of
endogenous and foreign chemicals, including: drugs, toxic chemicals, hormones, and …

Carbon tetrachloride (CCl 4 ) is a classical pericentral hepatotoxicant; however, precise
details of its mechanism of action remain unknown. One possibility is that Kupffer cells …

Medicinal plants are commonly used in Latin American folk medicine for the treatment of
gastric problems. In order to understand the properties of some of their chemical constituents, …

A uniform, predictable pattern of cellular abnormalities is seen after complete, irreversible
ischemic injury to the central nervous system. This is in contrast to the heterogeneous, …

The first alteration noted after denervation of the extensor digitorum longus muscles of rats
was a decrease in resting membrane potential (RMP) which occurred at about 2h. The exact …

Several investigators have suggested that certain hydroxylated metabolites of 17β-estradiol
(E 2 ) are the proximate carcinogens that induce mammary carcinomas in estrogen-sensitive …

1. The activities of the oxidative enzymes (glucose 6-phosphate dehydrogenase and 6-phosphogluconate
dehydrogenase) and of the non-oxidative enzymes (transaldolase, …

Several metabolites of the pentose phosphate pathway, together with related intermediates
of the Embden-Meyerhof pathway, were measured in cerebral tissue of mice after periods of …

Kupffer cells are activated by calcium and release a variety of toxic mediators, including
proteases. The purpose of these studies, therefore, was to determine if protease inhibitors and a …

Activities of glucuronosyltransferase, sulfotransferase, glutathione S-transferase, β-glucuronidase
and sulfatase were determined in microdissected samples of periportal and pericentral …