Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.
FA Fornari, JK Randolph, JC Yalowich, MK Ritke… - Molecular …, 1994 - ASPET
The capacity of doxorubicin to inhibit topoisomerase II in the MCF-7 breast tumor cell line is
supported by the induction of protein-associated single-strand breaks in DNA, as well as by …
supported by the induction of protein-associated single-strand breaks in DNA, as well as by …
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.
WD Jarvis, RN Kolesnick, FA Fornari… - Proceedings of the …, 1994 - National Acad Sciences
The potential involvement of ceramide-related signaling processes in the induction of apoptosis
by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the …
by tumor necrosis factor alpha was assessed by multiple biochemical strategies in the …
Coordinate regulation of stress-and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine
WD Jarvis, FA Fornari, KL Auer, AJ Freemerman… - Molecular …, 1997 - ASPET
We characterized participation of the stress-activated protein kinase (SAPK) cascade in the
lethal actions of the cytotoxic lipid messengers ceramide and sphingosine in U937 human …
lethal actions of the cytotoxic lipid messengers ceramide and sphingosine in U937 human …
[HTML][HTML] Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
WD Jarvis, FA Fornari, RS Traylor, HA Martin… - Journal of Biological …, 1996 - ASBMB
Prior studies demonstrated that ceramide promotes apoptotic cell death in the human myeloid
leukemia cell lines HL-60 and U937 (Jarvis, WD, Kolesnick, RN, Fornari, FA, Jr., Traylor, …
leukemia cell lines HL-60 and U937 (Jarvis, WD, Kolesnick, RN, Fornari, FA, Jr., Traylor, …
Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells.
WD Jarvis, FA Fornari, JL Browning, DA Gewirtz… - Journal of Biological …, 1994 - ASBMB
Prior studies demonstrated that increased intracellular availability of ceramide induces
apoptotic DNA degradation and cell death in the human leukemia cell lines HL-60 and U937 (…
apoptotic DNA degradation and cell death in the human leukemia cell lines HL-60 and U937 (…
Identification and hydropathic characterization of structural features affecting sequence specificity for doxorubicin intercalation into DNA double-stranded …
…, JN Scarsdale, FA Fornari Jr - Nucleic acids research, 1998 - academic.oup.com
The computer molecular modeling program HINT (Hydropathic INTeractions), an empirical
hydropathic force field function that includes hydrogen bonding, coulombic and hydrophobic …
hydropathic force field function that includes hydrogen bonding, coulombic and hydrophobic …
Growth arrest and non-apoptotic cell death associated with the suppression of c-myc expression in MCF-7 breast tumor cells following acute exposure to doxorubicin
FA Fornari Jr, WD Jarvis, S Grant, MS Orr… - Biochemical …, 1996 - Elsevier
In the MCF-7 human beast adenocarcinoma cell line, acute exposure to 1 μM doxorubicin
inhibited cell proliferation by ~75%. Analysis of cell cycle distribution indicated that within 24 hr…
inhibited cell proliferation by ~75%. Analysis of cell cycle distribution indicated that within 24 hr…
Induction of differentiation and growth arrest associated with nascent (nonoligosomal) DNA fragmentation and reduced c-myc expression in MCF-7 human breast …
FA Fornari Jr, WD Jarvis, S Grant, MS Orr… - Cell Growth and …, 1994 - AACR
The effects on DNA integrity of continuous (72-h) exposure of human MCF-7 breast adenocarcinoma
cells to 50 nM doxorubicin (a concentration which can be maintained in the plasma …
cells to 50 nM doxorubicin (a concentration which can be maintained in the plasma …
Evidence for involvement of mitogen-activated protein kinase, rather than stress-activated protein kinase, in potentiation of 1-β-D-arabinofuranosylcytosine-induced …
WD Jarvis, FA Fornari, RM Tombes, RK Erukulla… - Molecular …, 1998 - ASPET
The stress-activated protein kinase (SAPK) and mitogen-activated protein kinase (MAPK)
cascades mediate cytotoxic and cytoprotective functions, respectively, in the regulation of …
cascades mediate cytotoxic and cytoprotective functions, respectively, in the regulation of …
Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in …
…, JK Randolph, J Chawla, MS Orr, FA Fornari - Cancer chemotherapy …, 1998 - Springer
Purpose: Studies were designed to elucidate the basis for the antiproliferative activity of the
anthracycline antibiotic, idarubicin (4-demethoxy-daunorubicin) in MCF-7 breast tumor cells. …
anthracycline antibiotic, idarubicin (4-demethoxy-daunorubicin) in MCF-7 breast tumor cells. …