(3) All recent work on transannular N··· C= 0 interactions owes much to the early investigations
of Sir Robert Robinson and NJ Leonard. For an account of the early chemical and …

Dissolution tests have been in use in the pharmaceutical industry for over 20 years, and they
are official in The United States Pharmacopeia since the early 1960s. The dissolution test, …

Relative rates of dissolution of several crystalline steroids, xanthines, and other solid drugs
have been measured to determine the effect of solvate formation on this property. Equations …

… E.1. du Pont de Nemours und Co., Biomediul Products Deportment. Wilmrngtorz, DE I9898,
… MJ and Roberts, E., Effects of naloxone in senile dementia: a double-blind trial. N. E~gl. J. …

The crystal structures of 2, 6-dimethyl-3, 5-dicarbomethoxy-4-(2-nitrophenyl)-l, 4-dihydropyridine
(Nifedipine) and the 3-cyano-, 4-(dimethylamino)-and 2, 3, 4, 5, 6-pentafluorophenyl …

… Koshland, 1972; Kirby & Lancaster, 1972) arriving at results very similar to ours (Bfirgi,
Dunitz & Shefter, 1973). The known structures of the active sites of the hydrolytic enzymes …

The purpose of this investigation was to develop a method to quantitate insulin absorption,
and to compare insulin absorption from Various noninjection sites of administration. Log dose/…

Buccal delivery of opioid analgesics and antagonists is a useful way of improving bioavailability
relative to the oral route. These compounds taste bitter, however. Various prodrugs of …

… The effect of the substituents on activity was observed to be relatively independent of their
electronic character but correlated well with a parameter, Blt reflecting their size. In a previous …

A new technique for enhancing the solubility of peptides and proteins in organic solvents is
described. Complexation of polypeptides with stoichiometric amounts of an anionic detergent…