Several novel N-arylpiperazine derivatives were synthesized and tested for their 1) affinity
and functional activity on 5-hydroxytryptamine 1A (5-HT 1A ) receptors in vitro; 2) activity in …

WB4101 (1)-related compounds 5−10 were synthesized, and their biological profile at α 1 -adrenoreceptor
(AR) subtypes and 5-HT 1A serotoninergic receptors was assessed by …

Alpha adrenoceptor antagonists have been convincingly shown to be beneficial in reducing
both subjective and objective indices of urethral obstruction in benign prostatic hyperplasia. …

The α 1 -adrenoceptor subtypes present in the smooth muscle of urethra and prostate of
different animal species, including man, were characterized by using receptor binding …

In a search for structurally new α 1 -adrenoreceptor (α 1 -AR) antagonists, prazosin (1)-related
compounds 2−11 were synthesized and their affinity profiles were assessed by functional …

The aim of the present work was to investigate whether or not the uroselectivity of Rec 15/2739
and several other alpha-1 adrenoceptor (α 1 -AR) antagonists observed in the …

In the present study, more than 75 compounds structurally related to BMY 7378 have been
designed and synthesized. Structural variations of each part of the reference molecule have …

… Elena Poggesi … Elena Poggesi - Department of Chemical Sciences, University of Camerino,
Via S. … Banes, James E. Faber. Different α-adrenoceptors mediate migration of vascular …

… The maximal stimulation of [ 35 S]GTPγS binding (E max ) achieved for 6 was 23 and the
concentration required to obtain 50% of E max (pD 2 ) was 6.92. The results obtained in the [ 35 …

Novel 1,4-dioxane compounds structurally related to WB 4101 (1) were prepared in order to
investigate the possibility that the quite planar 1,4-benzodioxane template of 1 might be …