Comparison of the effects of zaleplon, zolpidem, and triazolam at various GABAA receptor subtypes

…, M Carta, F Massa, M Peis, E Maciocco… - European journal of …, 2002 - Elsevier
The pyrazolopyrimidine zaleplon is a hypnotic agent that acts at the benzodiazepine recognition
site of GABA A receptors. Zaleplon, like the hypnotic agent zolpidem but unlike classical …

Changes in expression and function of extrasynaptic GABAA receptors in the rat hippocampus during pregnancy and after delivery

…, G Talani, S Zucca, ML Mura, E Maciocco… - Journal of …, 2009 - Soc Neuroscience
Pregnancy is associated with changes in mood and anxiety level as well as with marked
hormonal fluctuations. Increases in the brain concentrations of neuroactive steroids during …

Social isolation‐induced increase in α4 and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor …

…, ML Mura, I Floris, E Maciocco, E Sanna… - Journal of …, 2006 - Wiley Online Library
Previously we have demonstrated that social isolation of rats reduces both the cerebrocortical
and plasma concentrations of 3α‐hydroxy‐5α‐pregnan‐20‐one (3α,5α‐TH PROG), and …

Clozapine, but not haloperidol, increases brain concentrations of neuroactive steroids in the rat

…, D Affricano, RH Purdy, E Maciocco… - …, 2001 - Elsevier
The extrapyramidal side effects of typical antipsychotics, which are induced to a markedly
reduced extent by clozapine, have been linked to a dysfunction of central γ-aminobutyric acid (…

Chronic treatment with hormonal contraceptives alters hippocampal BDNF and histone H3 post-translational modifications but not learning and memory in female rats

…, E Sanna, MG Pisu, G Calderisi, E Maciocco… - Hormones and …, 2022 - Elsevier
Hormonal contraceptives prevent ovulation with subsequent reduction in endogenous
levels of estradiol, progesterone and its neuroactive metabolite allopregnanolone. These …

Physicochemical characterization and in vivo properties of Zolpidem in solid dispersions with polyethylene glycol 4000 and 6000

…, MR Provenzano, E Sanna, E Maciocco… - International journal of …, 1999 - Elsevier
Solid dispersions and physical mixtures of Zolpidem in polyethylene glycol 4000 (PEG 4000)
and 6000 (PEG 6000) were prepared with the aim to increase its aqueous solubility. These …

Effects of voluntary ethanol consumption on emotional state and stress responsiveness in socially isolated rats

MG Pisu, MC Mostallino, R Dore, E Maciocco… - European …, 2011 - Elsevier
Social isolation of rats immediately after weaning is thought to represent an animal model of
anxiety-like disorders. This mildly stressful condition reduces the cerebrocortical and …

Increase in expression of the GABAA receptor α4 subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists

…, L Mancuso, F Biggio, A Manca, E Maciocco… - Molecular brain …, 2001 - Elsevier
The effects of long-term exposure to, and subsequent withdrawal of, diazepam or imidazenil
(full and partial agonists of the benzodiazepine receptor, respectively) on the abundance of …

Novel anellated pyrazoloquinolin-3-ones: synthesis and in vitro BZR activity

…, G Chiarelotto, S Dall'Acqua, E Maciocco… - Bioorganic & medicinal …, 2005 - Elsevier
… known for their high affinity for central benzodiazepine receptors (BZRs) and later papers
reported specific SARs and QSARs, indicating the structural requirements (lipophilic, electronic

Structure− activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine …

…, S Vomero, M Fresta, P Porcu, E Maciocco… - Journal of medicinal …, 2003 - ACS Publications
… Most electronic Supporting Information files are available without a subscription to ACS Web
Editions. Such files may be downloaded by article for research use (if there is a public use …