User profiles for E. Giacobini
ezio giacobiniuniversity of geneva hospitals Verified email at hcuge.ch Cited by 25139 |
The cholinergic system in the pathophysiology and treatment of Alzheimer's disease
…, MM Mesulam, AC Cuello, MR Farlow, E Giacobini… - Brain, 2018 - academic.oup.com
Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …
Sex differences in Alzheimer disease—the gateway to precision medicine
…, H Girouard, S Misoch, E Giacobini… - Nature Reviews …, 2018 - nature.com
… Initiative (ADNI) study: cognitive deterioration is faster in women than men over 1 year 31
and becomes twice as fast over 8 years 32 (even after normalization for apolipoprotein E (…
and becomes twice as fast over 8 years 32 (even after normalization for apolipoprotein E (…
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
The diagnosis of Alzheimer's disease can be improved by the use of biological measures.
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Biomarkers of functional impairment, neuronal loss, and protein deposition that can be …
Mild cognitive impairment–beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
…, C DeCarli, T Erkinjuntti, E Giacobini… - Journal of internal …, 2004 - Wiley Online Library
… Answers may be provided in future by currently ongoing clinical trials in MCI with several
AChEI, their combination with vitamin E and a piracetam trial. In the light of the current …
AChEI, their combination with vitamin E and a piracetam trial. In the light of the current …
Cholinergic function and Alzheimer's disease
E Giacobini - International journal of geriatric psychiatry, 2003 - Wiley Online Library
… (Giacobini, 1990; Giacobini, 2000). The synaptic cleft is a critical site because of the high (millimolar)
concentrations of acetylcholine (ACh) and glutamate found there, which trigger post-…
concentrations of acetylcholine (ACh) and glutamate found there, which trigger post-…
Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
…, I Bourquin, V Schiffer, A Calmy, JP Chave, E Giacobini… - Aids, 2010 - journals.lww.com
Objective: To determine the prevalence of cognitive complaints and HIV-associated
neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the …
neurocognitive disorders (HANDs) in a cohort of aviremic HIV-positive patients. To evaluate the …
Clinical trials and late‐stage drug development for A lzheimer's disease: an appraisal from 1984 to 2014
…, N Andreasen, H Feldman, E Giacobini… - Journal of internal …, 2014 - Wiley Online Library
… An earlier example was a 2-year trial of selegiline and vitamin E intended to delay loss of …
, an HMG-CoA reductase inhibitor or vitamin E and selenium 102. There have been two …
, an HMG-CoA reductase inhibitor or vitamin E and selenium 102. There have been two …
Cholinesterase inhibitors: new roles and therapeutic alternatives
E Giacobini - Pharmacological research, 2004 - Elsevier
… Further evidence for a role of BuChE in addition to that of AChE for maintaining cognitive
function in AD is provided by the study of Giacobini [16]. Central BuChE inhibition measured in …
function in AD is provided by the study of Giacobini [16]. Central BuChE inhibition measured in …
Alzheimer disease therapy—moving from amyloid-β to tau
E Giacobini, G Gold - Nature Reviews Neurology, 2013 - nature.com
… Despite the risk of vasogenic oedema (amyloid-related imaging abnormalities [ARIA]-E)—which
was observed in two of 28 patients treated with bapineuzumab in the PET imaging study …
was observed in two of 28 patients treated with bapineuzumab in the PET imaging study …
Cholinesterases: new roles in brain function and in Alzheimer's disease
E Giacobini - Neurochemical research, 2003 - Springer
… Giacobini, E. 1996. Cholinesterase inhibitors do more than inhibit cholinesterase. … and
Giacobini E. 1995. Coadministration of cholinesterase inhibitors and idazoxan: Effects of …
Giacobini E. 1995. Coadministration of cholinesterase inhibitors and idazoxan: Effects of …