Methods Male CD-i mice (Charles River Breeding Laboratories, Wilmington, MA) were
housed in our usual animal quarters at 25#{176} Cambient, with at ASPET Journals on …

The published data on pharmacokinetics of intravenously administered heparin were studied
by computer analysis. The relative volume(s) of distribution (RVD) and plasma half‐life (t ½ …

The absorption in 3 hours of benzomethamine from the small intestine has been studied in
vivo in unanesthetized rats using single- and multiple-loop preparations. Fasting of animals …

METHODS. Experiments were performed on four normal male subjects, ranging in age from
22-36 years, and in weight from 150-180 pounds(68-82 kgm.), during the summer and early …

… Ragozzino & Malone concluded from their data, as had Levine & Pelikan from similar data
obtained with a quaternary am monium drug (24), that some transfer process in addition to …

Curare, the South American arrow poison, is a brew concocted with ritual mystery from a
variety of plants by the witch doctor of certain tribes. The natives dip their arrow points into the …

MATERIALS AND METHODS Thirty patients with active myasthenia gravis, a diagnosis
previously made on the basis of clinical course, response to neostigmine therapy, response to …

1. Neostigmine, physostigmine, TEPP, and four 3-hydroxyphenyltrialkylam-monium compounds
have been quantitatively compared on the frog rectus abdominis muscle with regard to …

METHODS. The methods used were those previously described(1). Predetermined doses. of
the curarizing agent were administered intravenously to the unanesthetized volunteers who …

IN spite of the widespread clinical use of acetylsalicylic acid in both buffered and unbuffered
preparations, there is little information in the voluminous literature concerning the …