User profiles for E. R. Edelman
Elazer R. EdelmanProfessor of Health Sciences and Technology, MIT Verified email at mit.edu Cited by 41577 |
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior
…, AU Coskun, M Jonas, ER Edelman… - Journal of the American …, 2007 - jacc.org
Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …
Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
…, MH Donahee, A Rigotti, SN Iqbal, ER Edelman… - Nature, 1997 - nature.com
The risk of atherosclerosis, a leading cause of cardiovascular disease and death, is
inversely related to plasma levels of high-density lipoprotein (HDL) cholesterol, although the …
inversely related to plasma levels of high-density lipoprotein (HDL) cholesterol, although the …
Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings
…, VL Giddings, L Coleman, GK Wong, ER Edelman - Circulation, 2011 - Am Heart Assoc
… of Health to Dr Edelman ( R01 GM 49039 ) and an unrestricted gift from Abbott Vascular. …
Dr Edelman reports research support from Abbott Vascular , Boston Scientific , and Cordis Corp …
Dr Edelman reports research support from Abbott Vascular , Boston Scientific , and Cordis Corp …
Endovascular stent design dictates experimental restenosis and thrombosis
C Rogers, ER Edelman - Circulation, 1995 - Am Heart Assoc
Background Vascular interventions that maximize initial lumen diameter provoke extensive
neointimal hyperplasia but minimize its effects, causing long-term lumen size to be greater. …
neointimal hyperplasia but minimize its effects, causing long-term lumen size to be greater. …
Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo
M Simons, ER Edelman, JL DeKeyser, R Langer… - Nature, 1992 - nature.com
SYNTHETIC antisense oligonucleotides have been used to dissect gene function in vitro.
Technical difficulties prevented the use of this approach for investigating the effect of gene …
Technical difficulties prevented the use of this approach for investigating the effect of gene …
Physiological transport forces govern drug distribution for stent-based delivery
CW Hwang, D Wu, ER Edelman - Circulation, 2001 - Am Heart Assoc
Background The first compounds considered for stent-based delivery, such as heparin, were
chosen on the basis of promising tissue culture and animal experiments, and yet they have …
chosen on the basis of promising tissue culture and animal experiments, and yet they have …
Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology …
…, RG Gerrity, W Daley, C Rogers, ER Edelman… - Circulation, 2008 - Am Heart Assoc
Background— Low endothelial shear stress (ESS) promotes the development of
atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to …
atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to …
Controlled and modulated release of basic fibroblast growth factor
… data, MA Nugent and ER Edelman, 1990). Presumably this occurred because the coatings
occupied sites on the glass that would otherwise have bound the bFGF as it came into contact …
occupied sites on the glass that would otherwise have bound the bFGF as it came into contact …
Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo …
RJ Laham, FW Sellke, ER Edelman, JD Pearlman… - Circulation, 1999 - Am Heart Assoc
… This study was supported in part by NIH grants MO1-RR01032 (Dr Laham), HL-44821 (Dr
Simons), HL-56993 (Dr Pearlman), HL-46716 (Dr Sellke), and GM/HL-49039 (Dr Edelman). …
Simons), HL-56993 (Dr Pearlman), HL-46716 (Dr Sellke), and GM/HL-49039 (Dr Edelman). …
[HTML][HTML] Kruppel-like factor 4 regulates endothelial inflammation
…, MW Feinberg, RE Gerszten, ER Edelman… - Journal of Biological …, 2007 - ASBMB
The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory
cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-adhesive …
cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-adhesive …