Although the entire coronary tree is exposed to the atherogenic effect of the systemic risk
factors, atherosclerotic lesions form at specific arterial regions, where low and oscillatory …

The risk of atherosclerosis, a leading cause of cardiovascular disease and death, is
inversely related to plasma levels of high-density lipoprotein (HDL) cholesterol, although the …

… of Health to Dr Edelman ( R01 GM 49039 ) and an unrestricted gift from Abbott Vascular. …
Dr Edelman reports research support from Abbott Vascular , Boston Scientific , and Cordis Corp …

Background Vascular interventions that maximize initial lumen diameter provoke extensive
neointimal hyperplasia but minimize its effects, causing long-term lumen size to be greater. …

SYNTHETIC antisense oligonucleotides have been used to dissect gene function in vitro.
Technical difficulties prevented the use of this approach for investigating the effect of gene …

Background The first compounds considered for stent-based delivery, such as heparin, were
chosen on the basis of promising tissue culture and animal experiments, and yet they have …

Background— Low endothelial shear stress (ESS) promotes the development of
atherosclerosis; however, its role in the progression of atherosclerotic plaques and evolution to …

… data, MA Nugent and ER Edelman, 1990). Presumably this occurred because the coatings
occupied sites on the glass that would otherwise have bound the bFGF as it came into contact …

… This study was supported in part by NIH grants MO1-RR01032 (Dr Laham), HL-44821 (Dr
Simons), HL-56993 (Dr Pearlman), HL-46716 (Dr Sellke), and GM/HL-49039 (Dr Edelman). …

The vascular endothelium plays a critical role in vascular homeostasis. Inflammatory
cytokines and non-laminar blood flow induce endothelial dysfunction and confer a pro-adhesive …