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… For example, 1 out of every 70 people is a carrier of childhood lethal spinal muscular
atrophy(type I; Werdnig-Hoffman disease), a disease affecting approximately 1 in 20,000 newborns…

Immunological and inflammatory processes downstream of dystrophin deficiency as well as
metabolic abnormalities, defective autophagy, and loss of regenerative capacity all …

… Hoffman is the Harry Zimmerman post-doctoral fellow of the Muscular Dystrophy Association.
This work was supported by NIH grants ROI NS23740 (LM Kunkel) and NS00787-04 (RH …

The 14 kb human Duchenne muscular dystrophy (DMD) cDNA corresponding to a complete
representation of the fetal skeletal muscle transcript has been cloned. The DMD transcript is …

An important corollary to the recent advances in our understanding of the primary cause of
Duchenne muscular dystrophy 1–6 , is the validation of genuine genetic homologues as …

A deficiency of the protein dystrophin has recently been shown to be the probable cause of
Duchenne's muscular dystrophy. We sought to determine the relation between the clinical …

Results In cross and longitudinal sections of normal human muscle, dystrophin was localized
at the sarcolemma of the fibers. The cell surface of each muscle fiber showed a thin and …

It is intuitive to speculate that nutrient availability may influence differentiation of mammalian
cells. Nonetheless, a comprehensive complement of the molecular determinants involved in …

Purpose: This study assessed variability in muscle size and strength changes in a large
cohort of men and women after a unilateral resistance training program in the elbow flexors. A …