The effects of overexpression of Cu 2+ /Zn 2+ superoxide dismutase-1 (SOD-1) on indexes
of renal injury were compared in 5-month-old nontransgenic (NTg) db/db mice and db/db …

Diabetic nephropathy (DN) is a major cause of end-stage renal disease. Yet the pathogenic
mechanisms underlying the development of DN are not fully defined, partially due to lack of …

Pulmonary arterial hypertension (PH) is a deadly disease characterized by pulmonary
arterial vasoconstriction and hypertension, pulmonary vasculature remodeling, and right …

Background: Atopic dermatitis (AD) aetiology is not exactly identified, but it is characterized
by pruritic skin reactions with elevation in the levels of inflammatory markers. Despite the fact …

Our previous studies indicate that prolonged caffeine consumption exacerbates renal failure
in nephropathy associated with the metabolic syndrome. Reduced activity of the antioxidant …

Oxidative stress, that is, overproduction of reactive oxygen species and reduced antioxidant
system activity, is implicated in the pathogenesis of diabetic complications; and therefore, …

Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol (2HE),
an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In …

Heart failure with preserved ejection fraction (HFpEF), a prevalent form of heart failure, is
frequently accompanied by the metabolic syndrome and kidney disease. Because current …

ABSTRACT. It has been previously shown that 2-hydroxyestradiol (2-OHE) attenuates the
development of renal disease in genetic nephropathy associated with obesity and the …

Background Chronic spontaneous urticaria (CSU) is a common skin disorder affecting
negatively patients’ lives. Vitamin D deficiency has been reported to be associated to many …